Table 3 The pooled odds ratio of heart failure stratified by different glucose lowering strategies
Heart failure | ||||
|---|---|---|---|---|
Intervention | Conventional | Odds ratio (95 %CI) | I2 (%) | |
Overall | 1907/43,387 | 1610/41,824 | 1.17 (1.04, 1.31) | 57.8 |
Glucose-lowering strategies | ||||
Intensive control (ACCORD, ADVANCE, VADT, DIGAMI1, UKPDS34,33) | 559/14,968 | 515/13,454 | 1.00 (0.88, 1.13) | 0.0 |
Thiazolidinediones (PROactive, RECORD, BARI2D, AleCardio) | 712/9624 | 545/9655 | 1.39 (1.14, 1.69) | 59.2 |
Dipeptidyl peptidase inhibitors (SAVOR-TIMI53, EXAMINE, TECOS) | 623/18,238 | 546/18,157 | 1.14 (0.97, 1.34) | 41.9 |
Prandial vs basal strategy (HEART2D) | 13/557 | 4/558 | 3.31 (1.07, 10.21) | |