Variables | Control | HCD | Group × time interaction (P) | ||
---|---|---|---|---|---|
Baseline | Week 16 | Baseline | Week 16 | ||
Anthropometric | |||||
 Body weight (kg) | 97.8 ± 4.0 | 98.2 ± 4.2 | 98.6 ± 4.1 | 90.4 ± 4.0*** | <0.001 |
 Δ |  | 0.4 ± 0.4 |  | −8.1 ± 0.6‡ |  |
 Body mass index (kg/m2) | 32.8 ± 0.9 | 32.9 ± 1.0 | 33.9 ± 1.7 | 31.2 ± 1.7*** | <0.001 |
 Δ |  | 0.2 ± 0.2 |  | −2.7 ± 0.2‡ |  |
 Waist circumference (cm) | 106.1 ± 2.3 | 106.5 ± 2.2 | 107.8 ± 2.8 | 100.3 ± 2.8*** | <0.001 |
 Δ |  | 0.4 ± 0.4 |  | −7.5 ± 0.9‡ |  |
 Waist to hip ratio | 0.91 ± 0.02 | 0.92 ± 0.02 | 0.91 ± 0.02 | 0.89 ± 0.01*** | 0.001 |
 Δ |  | 0.0 ± 0.0 |  | −0.03 ± 0.01‡ |  |
 Total body fat mass (kg) | 38.0 ± 2.9 | 38.0 ± 3.0 | 42.0 ± 2.7 | 35.8 ± 3.1*** | <0.001 |
 Δ |  | 0.1 ± 0.3 |  | −6.2 ± 0.7‡ |  |
Metabolic and biochemical | |||||
 Fasting glucose (mmol/L) | 5.8 ± 0.1 | 5.9 ± 0.1 | 6.1 ± 0.2 | 5.8 ± 0.1** | 0.03 |
 Δ |  | 0.0 ± 0.1 |  | −0.3 ± 0.1†|  |
 Fasting insulin (mU/L) | 18.8 ± 1.7 | 20.4 ± 1.6* | 18.0 ± 1.4 | 13.8 ± 1.2***‡ | <0.001 |
 Δ |  | 1.7 ± 0.9 |  | −4.2 ± 0.7‡ |  |
 Triglycerides (mmol/L) | 1.5 ± 0.1 | 1.4 ± 0.1 | 1.7 ± 0.2 | 1.1 ± 0.1*** | 0.02 |
 Δ |  | −0.1 ± 0.1 |  | −0.6 ± 0.2†|  |
 HDL-cholesterol (mmol/L) | 1.29 ± 0.07 | 1.20 ± 0.06* | 1.21 ± 0.05 | 1.25 ± 0.07 | 0.02 |
 Δ |  | −0.09 ± 0.04 |  | 0.04 ± 0.03†|  |
 LDL-cholesterol (mmol/L) | 3.4 ± 0.1 | 3.4 ± 0.2 | 3.8 ± 0.2 | 3.5 ± 0.2** | 0.02 |
 Δ |  | 0.0 ± 0.1 |  | −0.3 ± 0.1†|  |
 NEFA (mEq/L) | 0.53 ± 0.04 | 0.51 ± 0.04 | 0.57 ± 0.05 | 0.55 ± 0.04 | 0.93 |
 Δ |  | −0.02 ± 0.03 |  | −0.02 ± 0.04 |  |
 Leptin (ng/mL) | 18.7 ± 4.6 | 19.1 ± 3.6 | 21.6 ± 4.7 | 13.1 ± 3.4*** | <0.001 |
 Δ |  | 0.4 ± 1.6 |  | −8.5 ± 2.1‡ |  |
 High sensitivity CRP (mg/L) | 3.3 ± 0.8 | 3.5 ± 0.9 | 3.2 ± 0.6 | 2.2 ± 0.4* | 0.12 |
 Δ |  | 0.2 ± 0.6 |  | −0.9 ± 0.3†|  |
 Creatinine clearance (mL/min) | 150 ± 11 | 147 ± 9 | 140 ± 10 | 118 ± 7**†| 0.06 |
 Δ |  | −3 ± 6 |  | −22 ± 10 |  |
Cardiovascular | |||||
 Clinic MAP (mmHg) | 92 ± 3 | 95 ± 3 | 89 ± 2 | 86 ± 2* | 0.007 |
 Δ |  | 3 ± 2 |  | −3 ± 1‡ |  |
 Clinic heart rate (bpm) | 62 ± 2 | 61 ± 2 | 62 ± 2 | 59 ± 2* | 0.41 |
 Δ |  | −2 ± 1 |  | −3 ± 1 |  |
 Cardiac BRS (ms/mmHg) | 15.7 ± 2.2 | 15.7 ± 1.9 | 18.0 ± 2.6 | 23.7 ± 2.9*†| 0.16 |
 Δ |  | 0.0 ± 2.2 |  | 5.8 ± 2.3 |  |
 Calf vascular resistance (units) | 53.0 ± 6.7 | 57.4 ± 4.4 | 51.3 ± 4.9 | 47.1 ± 3.3 | 0.18 |
 Δ |  | 4.4 ± 4.6 |  | −4.2 ± 3.9 |  |
 Finger reactive hyperaemic index | 2.35 ± 0.15 | 2.42 ± 0.16 | 2.38 ± 0.19 | 2.26 ± 0.15 | 0.44 |
 Δ |  | 0.07 ± 0.13 |  | −0.12 ± 0.20 |  |
 PAT ratio | 0.68 ± 0.09 | 0.67 ± 0.09 | 0.67 ± 0.10 | 0.62 ± 0.09 | 0.77 |
 Δ |  | −0.01 ± 0.10 |  | −0.05 ± 0.11 |  |
 Cardiac output (L/min) | 5.3 ± 0.3 | 5.6 ± 0.4 | 5.5 ± 0.4 | 5.4 ± 0.4 | 0.30 |
 Δ |  | 0.3 ± 0.2 |  | −0.1 ± 0.2 |  |