Fig. 4

Univariate correlates of change in whole-body insulin clearance and hepatic insulin extraction (fasting C-peptide to insulin ratio) in the HCD group (n = 17). a Change in fasting calf vascular resistance (r = −0.63, 0.007). b Change in steady state glucose utilization during euglycemic hyperinsulinemic clamp (M) (r = 0.45, P = 0.07). c Change in plasma HDL-cholesterol concentration (r = 0.53, P = 0.03). d Change in finger reactive hyperaemic index (r = 0.49 P = 0.04). e Change in Matsuda insulin sensitivity index (ISI) (r = 0.52, P = 0.03). f Change in glucose area under the curve (AUC_0–120) during oral glucose tolerance test (r = −0.61, P = 0.009)