Fig. 2
Change in sympathetic nervous system parameters in relation to change in body weight and insulin status in control and hypocaloric diet (HCD) groups (week 16 minus baseline measurements). HCD sub-groups are indicated by the hashed bars and include hyperinsulinemic (Hyper, n = 10) and normo-insulinemic (Normo, n = 7) subjects. a Body weight. b Insulin area under the curve during oral glucose tolerance test (AUC0–120). c Muscle sympathetic nerve activity (MSNA) burst incidence. d Arterial plasma norepinephrine (NE) concentration. e Norepinephrine plasma clearance. f Whole-body norepinephrine spillover rate. *P < 0.05, **P < 0.01 and ***P < 0.001 versus control group