Fig. 1

Changes in insulin sensitivity and insulin clearance in control and hypocaloric diet (HCD) groups (week 16 minus baseline measurements). a Homeostasis model assessment of insulin resistance (HOMA-IR): group × time interaction, P < 0.001. b Matsuda insulin sensitivity index (ISI): group × time interaction, P < 0.001. c Steady state glucose utilization during euglycemic clamp (M): group × time interaction, P = 0.02. d Fasting C-peptide to insulin ratio: group × time interaction, P = 0.06. e Insulin clearance: group × time interaction, P = 0.03. *P < 0.05 and ***P < 0.001 versus control group