Adjustment of the GRACE score by HemoglobinA1c enables a more accurate prediction of long-term major adverse cardiac events in acute coronary syndrome without diabetes undergoing percutaneous coronary intervention

Table 2 Univariate Cox analysis for MACEs

Variable	HR	95 % CI	p value
Age (per 1 year)	1.032	1.012–1.052	0.001
Male (vs. female)	0.910	0.480–1.725	0.772
BMI (per 1 kg/m²)	1.071	0.984–1.166	0.111
Hypertension	2.571	1.594–4.148	<0.001
Smoking	1.438	0.861–2.402	0.165
Prior MI	3.454	1.888–6.319	<0.001
Prior PCI	2.839	1.299–6.206	0.009
DBP (per 1 mmHg)	1.000	0.982–1.018	0.976
SBP (per 1 mmHg)	1.002	0.991–1.014	0.716
Heart rate (per 1 mmHg)	1.010	0.993–1.026	0.240
eGFR (per 1 mL min⁻¹ 1.73 m⁻²)	0.998	0.992–1.005	0.647
FBS (per 1 mmol/L)	0.976	0.856–1.112	0.712
TC (per 1 mmol/L)	1.013	0.820–1.252	0.903
TG (per 1 mmol/L)	0.787	0.566–1.094	0.153
HDL (per 1 mmol/L)	1.355	0.543–3.380	0.515
LDL (per 1 mmol/L)	1.048	0.767–1.432	0.766
Apo A1 (per 1 g/L)	0.926	0.248–3.451	0.908
Apo B (per 1 g/L)	0.955	0.338–2.697	0.931
LVEF (per 1 %)	0.965	0.945–0.985	0.001
NT-proBNP (per 1 ln unit)	1.236	1.052–1.451	0.010
PLT count (per 10⁹/L)	1.004	1.001–1.006	0.006
WBC count (per 10⁹/L)	1.035	0.966–1.109	0.326
Monocyte count (per 10⁹/L)	2.141	1.189–3.855	0.011
Neutrophile count (per 10⁹/L)	1.046	0.976–1.120	0.202
HbA1c content (per 1 %)	5.342	2.968–9.613	<0.001
GRACE score (per 1)	1.033	1.024–1.043	<0.001

ISSN: 1475-2840