Alterations in lipid transfers to HDL associated with the presence of coronary artery disease in patients with type 2 diabetes mellitus

Sprandel, Marilia C O; Hueb, Whady A; Segre, Alexandre; Ramires, José A F; Kalil-Filho, Roberto; Maranhão, Raul C

doi:10.1186/s12933-015-0270-8

Cardiovascular Diabetology

Table 4 Correlations between lipid transfers to HDL, serum concentrations of CETP, unesterified cholesterol and LCAT activity

From: Alterations in lipid transfers to HDL associated with the presence of coronary artery disease in patients with type 2 diabetes mellitus

Parameters	Lipid transfers				Unesterified cholesterol	LCAT activity	CETP concentration
Parameters	Unesterified cholesterol	Cholesteryl ester	Phospholipid	Triglyceride	Unesterified cholesterol	LCAT activity	CETP concentration
HDL-cholesterol	0.633^†	0.333^†	0.269^†	0.383^†	−0.088	−0.313^†	0.168
LDL-cholesterol	−0.005	0.218*	0.220^†	0.182*	0.416^†	−0.170	0.059
Tryglicerides	−0.229^†	0.103	−0.144	0.030	0.381^†	0.034	−0.012
non HDL-cholesterol	−0.078	0.212*	0.188*	0.180*	0.511^†	−0.120	0.050
TG/HDL-cholesterol	−0.322^†	0.046	−0.059	−0.044	0.403^†	0.083	−0.020
Unesterified cholesterol	−0.255^†	0.119	0.007	0.040	–	−0.044	0.058
Total/unesterified cholesterol	0.226^†	0.128	0.253^†	0.154	−0.402^†	−0.059	0.033
NEFA	0.490	0.044	−0.158	−0.054	0.003	0.265^†	−0.056
Fasting glucose	−0.154	0.081	−0.098	−0.108	0.148	0.100	0.018
HbA1_c	−0.022	0.027	−0.054	0.044	0.166*	−0.037	0.068
Apo A-I	0.697^†	0.584^†	0.316^†	0.334^†	−0.039	−0.383^†	0.305^†
Apo B	−0.219^†	0.091	0.109	0.096	0.617^†	−0.141	0.096
CETP concentration	0.185*	0.522^†	0.117	0.183*	0.058	−0.149	0.032
LCAT activity	−0.460^†	−0.235^†	−0.317^†	−0.283^†	−0.044	–	−0.056
Cholesteryl ester transfer	0.364^†	–	0.048	0.224^†	0.119	−0.235^†	0.522^†
Phospholipid transfer	0.568^†	0.048	–	0.576^†	0.007	−0.317^†	0.117
Unesterified cholesterol transfer	–	0.364^†	0.568^†	0.561^†	−0.255^†	−0.460^†	0.185*
Triglyceride transfer	0.561^†	0.224^†	0.576^†	–	0.040	−0.283^†	0.183*
HDL diameter	0.055	0.122	−0.099	−0.006	−0.150	0.037	0.100
HDL lipid composition
Unesterified cholesterol	0.321^†	0.121	0.057	0.204*	−0.218*	−0.111	0.181*
Tryglicerides	−0.134	0.185*	−0.151	−0.193*	−0.004	0.135	0.196*
Phospholipids	−0.161	−0.035	−0.036	−0.129	0.123	0.037	−0.176
Cholesteryl ester	0.141	−0.084	0.091	0.170	−0.066	−0.066	0.049

BMI Body mass index, HDL high density lipoprotein, LDL low density lipoprotein, TG triglycerides, UC unesterified cholesterol, HbA1 _c glycated hemoglobin, Apo apolipoprotein, CETP cholesteryl ester transfer protein, LCAT lecithin-cholesterol acyltransferase, NEFA non-esterified fatty acids.
* p value <0.05.
^†p value <0.01.

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ISSN: 1475-2840

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