Coronary microvascular and epicardial endothelial function according to HbA1c level. a Values of CFR (endothelial independent CMD) according to glycaemic control. b Values (in percentages) of increase in CBF after Ach intracoronary infusion (endothelial dependent CMD). c Values (in percentages) of increase in CLD after Ach intracoronary infusion (epicardial endothelial dysfunction). CFR coronary flow reserve; CMD coronary micro vascular dysfunction; CFR < 2.5 endothelial independent CMD; CBF%Ach percentage of increase in CBF after intracoronary acetylcholine infusion; CBFAch < 50 % endothelial dependent CMD; CLD%Ach percentage of increase in coronary lumen diameter after intracoronary acetylcholine infusion; CLDAch < 20 % epicardial endothelial dysfunction. *p < 0.05; **p < 0.001.