Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in type 1 diabetes

Monnier, Vincent M; Sun, Wanjie; Gao, Xiaoyu; Sell, David R; Cleary, Patricia A; Lachin, John M; Genuth, Saul

doi:10.1186/s12933-015-0266-4

Cardiovascular Diabetology

Table 3 Associations of AGEs with sub-clinical cardiovascular disease outcomes

From: Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in type 1 diabetes

	N	Furosine	CML	Pentosidine	Pepsin soluble	Acid soluble	CEL	G-H1	MG-H1	Glucosepane
Coronary artery calcification
CAC score (correlation coefficient, p value, FDR^#)^{^}	187	0.16* 0.026 (0.143)	0.12 0.09	0.12 0.11	−0.14 0.57	0.05 0.47	−0.08 0.26	0.11 0.11	0.04 0.55	0.07 0.33
CAC score = 0 vs. CAC score >0 (mean ± std)	131	749 (240)	528 (129)	25.3 (6.7)	6.7 (3.1)	0.5 (0.3)	151 (103)	61 (28)	0.8 (0.5)	2.6 (0.6)
CAC score = 0 vs. CAC score >0 (mean ± std)	56	817 (230)	560 (148)	27.6 (8.5)	6.3 (2.5)	0.6 (0.4)	146 (124)	71 (38)	0.8 (0.5)	2.5 (0.7)
P Value (FDR)^+,#		0.039	0.13	0.15	0.76	0.32	0.22	0.12	0.7	0.32
CAC score <100 vs. CAC score >100 (mean ± std)	170	766 (241)	535 (135)	25.8 (7.4)	6.6 (3.0)	0.5 (0.3)	148 (108)	64 (30)	0.8 (0.4)	2.6 (0.6)
CAC score <100 vs. CAC score >100 (mean ± std)	17	808 (223)	567 (142)	27.2 (6.3)	5.9 (2.7)	0.6 (0.6)	162 (130)	72 (41)	0.9 (0.5)	2.6 (0.7)
P-Value (FDR)^+,#		0.32	0.25	0.38	0.27	0.73	0.87	0.49	0.29	0.65
Common IMT (correlation)
Year 6	127	0.17	0.14	0.13	−0.11	0.02	0.10	−0.06	0.21*	0.19*
Change: year 6–year 1	127	0.04 0.68	0.04 0.20	0.23* 0.01	−0.20 * 0.016	0.02 0.94	0.07 0.29	0.05 0.45	0.22* 0.059	0.18* 0.047
Year 12	127	0.15	0.06	−0.04	0.00	0.02	0.05	−0.02	0.06	0.16
Change: year 12–year 1	127	0.07	0.06	0.02	−0.13	−0.05	0.03	0.10	0.01	0.15
Cardiac MRI studies
LV Mass (g)	142	0.10 0.25	0.16 0.058	0.14 0.11	−0.17* 0.04	−0.16 0.054	−0.02 0.83	0.03 0.75	0.17* 0.049	0.07 0.44
End diastolic volume (ml)	142	−0.05	−0.02	0.09	−0.10	−0.10	0.06	−0.12	0.00	−0.07
End systolic volume (ml)	142	−0.06	−0.02	0.07	−0.07	0.00	0.07	−0.06	0.01	−0.09
Stroke volume (ml)	142	−0.03	−0.03	0.07	−0.07	−0.12	0.04	−0.10	−0.03	−0.03
Cardiac (L/min)	142	0.14	0.02	0.06	−0.08	−0.08	0.01	−0.01	−0.08	0.05
Ejection fraction (%)	142	0.02	−0.05	−0.07	0.05	−0.07	−0.02	−0.04	−0.04	0.01
LV mass/end diastolic volume (g/ml)	142	0.18*	0.22**	0.08	−0.13	−0.13	−0.05	0.09	0.19*	0.15

Italic values indicate statistically significant associations
* p < 0.05, ** p < 0.01.
^{^}Analyses of correlations and their associated p values used Spearman correlations.
⁺P values between categorical results were generated using the Wilcoxon two sample test.
^#Numbers in parentheses are the Benjamini and Hochberg’s FDR alpha adjustment.

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