Table 2 Subclinical cardiovascular outcomes of the skin biopsy study participants during EDIC
| Â | Primary | Secondary | P value |
|---|---|---|---|
Intima-media thickening study (NÂ =Â 127) | |||
 EDIC year 1 | 6 (0.7) | 6.2 (0.8) |  |
 EDIC year 6 | 6.2 (0.8) | 6.5 (0.8) | 0.003 |
 EDIC year 12 | 6.8 (0.9) | 7.1 (1.1) |  |
Coronary calcium study (NÂ =Â 187) | |||
 CAC Mean (Agatston units) | 23 (109.2) | 91.7 (281) | 0.002 |
Cardiac MRI studies (NÂ =Â 142) | |||
 Left ventricular end diastolic mass (g) | 146.6 (33.2) | 149.6 (35.8) |  |
 End diastolic volume (ml) | 144.1 (34.4) | 140.6 (31.6) |  |
 End systolic volume (ml) | 56.5 (16.3) | 55.4 (17.7) |  |
 Stroke volume (ml) | 87.5 (21.7) | 85.2 (19.4) |  |
 Cardiac output (L/min) | 6 (1.5) | 5.9 (1.3) |  |
 Ejection fraction (%) | 60.8 (5) | 61 (6.9) |  |
 LV mass/end diastolic volume (g/ml) | 1 (0.2) | 1.1 (0.2) |  |