Fig. 8
Effect of vildagliptin on Beclin-1/Bcl-2 interaction after MI in OLETF. a Representative images (left) and summary data (right) of Western blotting for Beclin-1 and Bcl-2 in samples from sham-operated heats or the non-infarcted myocardium after MI in LETO and OLETF. b Effects of vildagliptin (Vilda) and exenatide (Exe) on Beclin-1 and Bcl-2 levels in the non-infarcted myocardium after MI in OLETF. Representative immunoblotting images (left) and summary data (right) are shown. c Myocardial lysates were immunoprecipitated (IP) with anti-Beclin-1 antibody or rabbit IgG followed by immunoblotting with anti-Bcl-2 and Beclin-1 antibodies. d, e Beclin-1/Bcl-2 interaction was increased after MI in OLETF, which was attenuated by vildagliptin (Vilda). N = 5 in each group. *p < 0.05. a.u. arbitrary units.