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Fig. 7 | Cardiovascular Diabetology

Fig. 7

From: Histone deacetylase (HDAC) inhibition improves myocardial function and prevents cardiac remodeling in diabetic mice

Fig. 7

HDAC inhibition reduced apoptosis in STZ-induced diabetic heart. a Representative Western blots of active caspase-3. b densitometric analysis of active caspase-3 proteins. c Quantitative analysis of terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL)-positive nuclei in myocardium in different groups. d Representative images of TUNEL stainings in myocardial sections. Nuclei were stained in blue (DAPI) and cardiomyocytes in red (α-sarcomeric actinin); TUN EL-positive nuclei were stained in green. α-Sarc Act α-sarcomeric actinin; Values are shown as mean ± SEM (n = 3 per group for Western blots, n = 5 per group for TUNEL); *p < 0.05 vs CTRL, # p < 0.05 vs STZ+ NaBu. NaBu sodium butyrate. Scale bar 100 µm.

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