Skip to main content

Table 1 Coronary flow, end-diastolic pressure (EDP) and heart rate (HR) under baseline vs. high glucose perfusion conditions with ischemia–reperfusion

From: Partial inhibition of the ubiquitin–proteasome system ameliorates cardiac dysfunction following ischemia–reperfusion in the presence of high glucose

 

Coronary flow (ml/min)

EDP (mmHg)

HR (beats/min)

Pre-ischemia

Post-ischemia

Pre-ischemia

Post-ischemia

Pre-ischemia

Post-ischemia

Control

10 ± 2.3

8.2 ± 1.3

14 ± 0

33 ± 5

200 ± 12

240 ± 18

 +5 µM lactacystin

8.4 ± 1

7.5 ± 1.5

10 ± 1

29 ± 7

235 ± 8

278 ± 14

 +10 µM MG-132

12 ± 1

8 ± 2.4

11 ± 2

31 ± 2

236 ± 10

268 ± 15

High glucose

11.2 ± 1.8

6 ± 1.5

8 ± 3

65 ± 7*

347 ± 13*

244 ± 9

 +5 µM lactacystin

10 ± 2.3

8.2 ± 1.3

14 ± 0

33 ± 5**

355 ± 8

248 ± 12

 +10 µM MG-132

9 ± 2

11.2 ± 0.6*

15 ± 3

26 ± 7***

306 ± 10

288 ± 8

  1. All values were recorded during the first 10 min of stabilization (“Pre-ischemia”) and at the end of reperfusion (“Post-ischemia”) and are expressed as mean ± SEM. *p < 0.05; **p < 0.01 vs. respective controls, (n = 8 per group).
Back to article page

Cardiovascular Diabetology

ISSN: 1475-2840