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Fig. 6 | Cardiovascular Diabetology

Fig. 6

From: Partial inhibition of the ubiquitin–proteasome system ameliorates cardiac dysfunction following ischemia–reperfusion in the presence of high glucose

Fig. 6

Comparative analysis of UPS inhibition on contractile function during ischemia–reperfusion. Isolated rat hearts were perfused under high glucose conditions (33 mM glucose) vs. controls (11 mM glucose) for 60 min and subsequently subjected to 20 min of global ischemia, followed by 60 min of reperfusion. Either 5 μM lactacystin or 10 μM MG-132 was added during the first 20 min of reperfusion. a Left ventricular developed pressure (LVDP) (% recovery) at baseline glucose levels (11 mM), and b with high glucose (33 mM). Rate pressure product (RPP) (% recovery) at baseline glucose levels (c), and d under high glucose conditions. Values are expressed as mean ± SEM (n = 8). *p < 0.05, **p < 0.01, ***p < 0.001 vs. respective controls.

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Cardiovascular Diabetology

ISSN: 1475-2840