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Fig. 4 | Cardiovascular Diabetology

Fig. 4

From: Partial inhibition of the ubiquitin–proteasome system ameliorates cardiac dysfunction following ischemia–reperfusion in the presence of high glucose

Fig. 4

Lactacystin administration improves contractile function during ischemia–reperfusion. Isolated rat hearts were perfused under high glucose conditions (33 mM glucose) vs. controls (11 mM glucose) for 60 min and thereafter subjected to 20 min of global ischemia, followed by 60 min of reperfusion. Lactacystin (5 μM) was added to treatment groups during the first 20 min of reperfusion. a Left ventricular developed pressure (LVDP) (% recovery) at baseline glucose levels (11 mM), and c with high glucose (33 mM). Rate pressure product (RPP) (% recovery) at baseline glucose levels (b), and d under high glucose conditions. Values are expressed as mean ± SEM (n = 8).*p < 0.05, **p < 0.01 vs. respective controls.

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Cardiovascular Diabetology

ISSN: 1475-2840