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Table 2 Load dependent indices of left ventricular function as measured by pressure–volumetry from Experiment 1

From: Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing myosin cross-bridge extension

 

Control

Diabetic

Diabetic + fasudil

Heart rate (BPM)

350 ± 12

290 ± 12**

299 ± 13**

End systolic pressure (mmHg)

127 ± 6

95 ± 9**

115 ± 5

End diastolic pressure (mmHg)

7.5 ± 0.9

7.8 ± 1

8.7 ± 1

Stroke volume (μl)

168 ± 20

184 ± 8

193 ± 17

Cardiac output (ml/min)

59.4 ± 8.1

53.5 ± 3.5

57.7 ± 5.6

Ejection fraction (%)

66 ± 8

60 ± 7

50 ± 3

dP/dtmaximum (mmHg/s)

7,391 ± 602

6,616 ± 470

7,096 ± 641

dP/dtminimum (mmHg/s)

−8,210 ± 632

−5,917 ± 502*

−6,439 ± 569*

Tau Glantz (ms)

12 ± 0.3

14.4 ± 0.7*

14.2 ± 0.8*

  1. Data expressed as mean ± SEM.
  2. dP/dtmaximum, maximum rate of left ventricular pressure development; dP/dtminimum, minimum rate of left ventricular pressure decay.
  3. * P < 0.05 and ** P < 0.01 vs. control rats.
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Cardiovascular Diabetology

ISSN: 1475-2840