Rutin administration attenuates myocardial dysfunction in diabetic rats

Table 2 Echocardiographic structural data

Parameters	C (n = 14)	C-R (n = 14)	DM (n = 16)	DM-R (n = 16)
HR (bpm)	292 ± 33	293 ± 32	271 ± 57	283 ± 30
LVDD (mm)	8.12 ± 0.42	8.21 ± 0.36	8.30 ± 0.46	8.35 ± 0.51
LVSD (mm)	3.75 ± 0.57	3.91 ± 0.34	4.26 ± 0.36*	3.97 ± 0.50
PWT (mm)	1.53 ± 0.11	1.53 ± 0.10	1.46 ± 0.07	1.34 ± 0.06^#
SWT (mm)	1.65 ± 0.05	1.63 ± 0.08	1.48 ± 0.10*	1.40 ± 0.07^#§
LA (mm)	5.76 ± 0.64	6.03 ± 0.71	5.73 ± 0.56	5.36 ± 0.53^#
LVDD/BW (mm/kg)	18.4 ± 1.81	19.2 ± 2.11	29.2 ± 3.07*	24.7 ± 3.26^#§
LA/BW (mm/kg)	13.0 ± 1.59	14.1 ± 2.47	20.1 ± 2.09*	16.0 ± 2.85^§
LVM (g)	0.94 ± 0.10	0.95 ± 0.10	0.89 ± 0.12	0.81 ± 0.11^#
LVM/BW (g/kg)	2.13 ± 0.25	2.23 ± 0.30	3.12 ± 0.47*	2.38 ± 0.23^§
RWT	0.38 ± 0.04	0.38 ± 0.04	0.36 ± 0.02*	0.32 ± 0.02^#§

Data are expressed as mean ± standard deviation. One-way ANOVA in a factorial design 2 × 2 and Tukey’s post hoc test.
C untreated rats, C-R rutin-treated rats, DM untreated diabetic rats, DM-R rutin-treated diabetic rats, HR heart rate, LVDD and LVSD left ventricular (LV) diastolic and systolic diameter, respectively, PWT LV posterior wall thickness, SWT septal wall thickness, LA left atrial diameter, LVM LV mass, RWT relative wall thickness, BW body weight.
* p < 0.05 vs C; ^#p < 0.05 vs C-R; ^§ < 0.05 vs DM.

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