Platelet hyperactivity and fibrin clot structure in transient ischemic attack individuals in the presence of metabolic syndrome: a microscopy and thromboelastography® study

Table 5 Summary of the findings of this manuscript according to techniques used

Technique	Platelets	Fibrin networks	Conclusions drawn
SEM	Platelet activation present seen with presence of pseudopodia and spreading	Denser, less organized fibrin networks in experimental group	Platelet activation present, altered fibrin network formation with the addition of thrombin affecting clot characteristics and possibly the hemostatic process
	Platelet aggregation present in the experimental group	Thick major fibers sticky and clumped together and thicker than fibers in healthy individuals	These alterations may be due to changes in elasticity
	Platelet aggregation present in the experimental group	Fibers making up clots of the experimental group were less taut with visible fibrin fiber ends not found in the healthy group	These alterations may be due to changes in elasticity
AFM	Platelets are less elastic in the diseased individuals	Fibrin fibers are less elastic in the experimental group	A decrease in platelet elasticity affects platelet contraction and therefore clot retraction, resulting in altered fibrin network elasticity and network morphology
TEG^®	N/A	N/A	TEG^® was used to determine whether the alterations obtained with the results of the other techniques affected the hemostatic profile of the individuals, but was found not affect the overall coagulation process

ISSN: 1475-2840