Table 1 Medication and the effect on coagulation

Anticoagulant

4

Warfarin, Xarelto, Clexane

Decrease production of coagulation factors by the liver.

[41]

Cox-1 inhibitor

12

Ecotrin, Disprin CV, Disprin

Inhibits cox-1 activity thereby preventing the production of TXA₂ and platelet aggregation

[42]

P2Y₁₂-inhibitor

5

Plavix (Clopidogrel)

Prevents release of ADP and thereby the activation of platelets and subsequent platelet aggregation

[43]

β-blocker

6

Adco-biscor, Bilocor, Tenbloka, Bisoprolol, Hypotone, Carloc

Down regulates TXA₂ production, but not platelet aggregation and therefore not significant effect on coagulation

[43]

Decreased fasting glucose agent

4

Arrow metformin, Glucophage, Galvus, Starlix

Decreases the amount of PAI-1 available, thereby influencing fibrinolysis

[44]

Synthetic insulin

1

Levemir

Hyperinsulinaemia may decrease fibrinolysis, so treatment can normalise fibrinolytic activity

[45]

GABA derivatives

2

Nootropil

Appears to have an antithrombotic effect, but mechanism not elucidated as yet

[46]