Table 5 Genes significantly up-regulated in diabetes MVT-treated vs. diabetes vehicle-treated group on DNA microarray
Diabetes MVT | Diabetes Vehicle | Control MVT | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
vs. | vs. | vs. | ||||||||
Diabetes Vehicle | Control Vehicle | Control Vehicle | ||||||||
Gene function | Gene Name provided by RGD a | Acc. Number | Gene Symbol | Log2 (SD) | Corr. p | Fold change | Log2 (SD) | Fold Change | Log2 (SD) | Fold Change |
Metabolism | L-2-hydroxyglutarate dehydrogenase | NM_001108028 | L2hgdh | 1.06 (0.49) | 0.032 | 2.09 | −0.52 (1.01) | −1.44 | 0.04 (0.92) | 1.03 |
Apoptosis/necrosis and inflammation | chemokine (C-X-C motif) ligand 9 | NM_145672 | Cxcl9 | 1.03 (0.40) | 0.021 | 2.04 | −0.29 (0.60) | −1.22 | −0.19 (0.81) | −1.14 |
Apoptosis/necrosis and inflammation | caspase recruitment domain family, member 9 | NM_022303 | Card9 | 1.82 (0.52) | 0.007 | 3.53 | −2.74 (0.64) | −6.69 | −1.20b (0.88) | −2.29 |
Receptors and ion channels | adrenoceptor alpha 1D | NM_024483 | Adra1d | 1.12 (0.40) | 0.017 | 2.17 | −1.21 (0.52) | −2.31 | −1.03b (1.36) | −2.04 |
Receptors and ion chanells | FXYD domain-containing ion transport regulator 3 | NM_172317 | Fxyd3 | 1.97 (0.48) | 0.004 | 3.92 | −1.01 (0.49) | −2.01 | −0.36 (0.85) | −1.29 |
Signal transduction, regulation of transcription | regulator of telomere elongation helicase 1 | NM_001191857 | Rtel1 | 1.14 (0.27) | 0.006 | 2.20 | −0.71 (1.02) | −1.64 | 0.58 (1.14) | 1.49 |
Signal transduction, regulation of transcription | staufen double-stranded RNA binding protein 2 | NM_001007149 | Stau2 | 1.36 (0.71) | 0.042 | 2.56 | −0.38 (0.27) | −1.30 | 0.22 (0.41) | 1.16 |
Structural protein, cell adhesion | protocadherin 17 | NM_001107279 | Pcdh17 | 0.90 (0.43) | 0.036 | 1.86 | −0.94 (0.44) | −1.91 | −0.65 (0.43) | −1.57 |
Hormones | inhibin alpha | NM_012590 | Inha | 1.59 (0.79) | 0.035 | 3.01 | −0.89 (0.39) | −1.85 | 0.66 (0.21) | 1.58 |
Others | similar to HTGN29 protein; keratinocytes associated transmembrane protein 2 | NM_001106999 | RGD131352 | 1.05 (0.48) | 0.032 | 2.07 | 0.29 (0.49) | 1.23 | 0.49 (0.53) | 1.41 |
Others | WDNM1 homolog | NM_001003706 | LOC360228 | 1.32 (0.63) | 0.033 | 2.50 | −0.59 (0.77) | −1.50 | 1.01b (0.67) | 2.01 |
Others | ring finger protein 135 | NM_001012010 | Rnf135 | 0.86 (0.33) | 0.023 | 1.82 | −0.44 (0.08) | −1.35 | −0.06 (0.46) | −1.05 |
Others | uncharacterized LOC100910110 | XR_146304 | LOC100910110 | 2.32 (0.31) | 0.001 | 5.01 | −1.94 (0.32) | −3.85 | −0.46 (1.57) | −1.38 |
Others | uncharacterized LOC100909684 | XR_146107 | LOC10099684 | 2.55 (1.40) | 0.045 | 5.85 | −3.07 (1.43) | −8.43 | −0.42 (0.76) | −1.34 |
Others | serine hydrolase-like 2 | NM_001130579 | Serhl2 | 5.17 (0.48) | <0.001 | 35.96 | −3.62b (2.81) | −12.31 | −3.45b (2.82) | −10.92 |