Table 3 Genes significantly up-regulated in diabetes vehicle-treated vs. control vehicle-treated group on DNA microarray

Metabolism

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15

XM_003752864

Galnt15

0.85 (0.53)

0.047

1.81

−0.58 (0.40)

−1.49

0.32 (0.55)

1.25

Metabolism

microtubule associated monooxygenase, calponin and LIM domain containing 1

NM_001106397

Mical1

0.89 (0.23)

0.007

1.86

−0.21 (0.19)

−1.16

0.52 (0.23)

1.43

Metabolism

proline dehydrogenase (oxidase) 1

NM_001135778

Prodh

0.95 (0.48)

0.026

1.93

−0.27 (0.63)

−1.21

0.93 (0.50)

1.91

Metabolism

4-hydroxyphenylpyruvate dioxygenase

NM_017233

Hpd

1.07 (0.38)

0.011

2.09

−0.06 (0.34)

−1.04

1.00 (0.48)

2.01

Stress response

glutathione S-transferase, theta 3

NM_001137643

Gstt3

0.88 (0.52)

0.042

1.84

−0.13 (0.38)

−1.09

0.61 (0.80)

1.52

Stress response

heme oxygenase (decycling) 1

NM_012580

Hmox1

1.08 (0.47)

0.017

2.12

−0.62 (0.49)

−1.54

0.52 (0.25)

1.43

Stress response

metallothionein 1a

NM_138826

Mt1a

1.32 (0.34)

0.005

2.49

−1.18 (0.43)

−2.26

0.09 (0.39)

1.06

Stress response

metallothionein 2a

NM_001137564

Mt2a

1.61 (0.34)

0.003

3.06

−1.70 (0.66)

−3.24

0.24 (0.53)

1.18

Immune response

NLR family member X1

NM_001025010

Nlrx1

0.87 (0.48)

0.036

1.83

−1.07 (0.43)

−2.10

0.30 (0.43)

1.23

Immune response

FK506 binding protein 5

NM_001012174

Fkbp5

1.13 (0.52)

0.020

2.19

−1.09 (0.32)

−2.13

0.83 (0.74)

1.77

Immune response

influenza virus NS1A binding protein

NM_001047085

Ivns1abp

1.27 (0.40)

0.008

2.41

−0.65 (0.35)

−1.57

0.68 (0.79)

1.60

Apoptosis/necrosis and inflammation

interleukin 6 receptor

NM_017020

Il6r

0.91 (0.50)

0.034

1.88

−1.00 (0.47)

−2.00

0.63 (0.67)

1.54

Cell growth and differentiation

H19, imprinted maternally expressed transcript

NR_027324

H19

0.92 (0.49)

0.032

1.89

−0.53 (0.47)

−1.44

1.16 (0.44)

2.24

Cell growth and differentiation

secreted frizzled-related protein 2

NM_001100700

Sfrp2

1.22 (0.73)

0.039

2.34

−0.62 (0.77)

−1.54

0.87^b (0.73)

1.83

Cell growth and differentiation

wingless-type MMTV integration site family, member 2B

NM_001191848

Wnt2b

1.32 (0.11)

0.003

2.50

−1.66 (0.48)

−3.15

0.16 (0.11)

1.11

Cell growth and differentiation

brain expressed, X-linked 1

NM_001037365

Bex1

1.41 (0.30)

0.003

2.65

−1.97 (0.45)

−3.92

0.25 (0.81)

1.19

Cell growth and differentiation

N-myc downstream regulated 1

NM_001011991

Ndrg1

0.85 (0.42)

0.027

1.81

−1.05 (0.33)

−2.07

0.41 (0.62)

1.33

Receptors and ion channels

solute carrier family 26 (anion exchanger), member 3

NM_053755

Slc26a3

0.88 (0.34)

0.015

1.84

−0.03 (0.23)

−1.02

0.01 (0.32)

1.01

Receptors and ion channels

ATPase, H⁺ transporting, lysosomal V1 subunit G2

NM_212490

Atp6v1g2

0.92 (0.41)

0.020

1.89

−1.05 (0.43)

−2.06

−0.75 (0.22)

−1.68

Receptors and ion channels

ATP-binding cassette, subfamily A (ABC1), member 1

NM_178095

Abca1

1.01 (0.35)

0.011

2.01

−0.22 (0.39)

−1.17

0.54 (0.40)

1.45

Receptors and ion channels

sarcolipin

NM_001013247

Sln

1.07 (0.61)

0.036

2.10

−0.23 (0.42)

−1.17

1.09 (0.61)

2.13

Signal transduction, regulation of transcription

zinc finger and BTB domain containing 16

NM_001013181

Zbtb16

0.89 (0.29)

0.011

1.85

−0.69 (0.33)

−1.62

0.37 (0.52)

1.30

Signal transduction, regulation of transcription

Rho-related BTB domain containing 1

NM_001107622

Rhobtb1

0.91 (0.25)

0.008

1.88

−0.22 (0.25)

−1.16

0.58 (0.55)

1.49

Signal transduction, regulation of transcription

connector enhancer of kinase suppressor of Ras 1

NM_001039011

Cnksr1

1.31 (0.67)

0.025

2.48

−1.64 (0.38)

−3.13

0.39 (0.72)

1.31

Signal transduction, regulation of transcription

cytochrome P450, family 26, subfamily b, polypeptide 1

NM_181087

Cyp26b1

1.62 (0.28)

0.003

3.08

−1.68 (0.47)

−3.20

0.25 (0.30)

1.19

Structural protein, cell adhesion

pannexin 2

NM_199409

Panx2

0.97 (0.17)

0.003

1.96

−0.56 (0.33)

−1.47

0.81 (0.15)

1.75

Structural protein, cell adhesion

myosin light chain kinase 2

NM_057209

Mylk2

1.17 (0.32)

0.006

2.25

−0.05 (0.37)

−1.03

1.05^b (0.69)

2.08

Hormones

resistin

NM_144741

Retn

1.08 (0.60)

0.034

2.12

−1.03 (0.44)

−2.05

0.51 (0.96)

1.43

Hormones

galanin/GMAP prepropeptide

NM_033237

Gal

2.41 (1.15)

0.018

5.31

−2.99 (0.92)

−7.96

1.82^b (1.20)

3.53

Hormones

natriuretic peptide A

NM_012612

Nppa

1.23 (0.45)

0.011

2.34

−0.62 (0.42)

−1.54

0.79 (0.38)

1.73

Others

myosin binding protein H-like

NM_001014042

Mybphl

1.26 (0.75)

0.038

2.39

−0.66 (0.68)

−1.58

1.09^b (0.71)

2.13

Others

prostaglandin D2 synthase (brain)

NM_013015

Ptgds

1.32 (0.69)

0.026

2.50

−0.64 (0.46)

−1.56

0.67 (0.87)

1.59

Others

visinin-like 1

NM_012686

Vsnl1

1.49 (0.79)

0.026

2.80

−1.01^b (0.77)

−2.01

1.16^b (0.76)

2.24

Others

transmembrane protein 140

NM_001009709

Tmem140

1.49 (0.27)

0.003

2.80

−0.59 (0.42)

−1.50

0.30 (0.26)

1.23

Others

IQ motif and ubiquitin domain containing

NM_001034130

Iqub

0.94 (0.36)

0.014

1.91

0.23 (0.20)

42021

0.52 (0.59)

1.44

Others

similar to apolipoprotein L2; apolipoprotein L-II

NM_001134801

RGD1309808

4.33 (2.91)

0.049

42358

−6.07 (0.68)

−67.24

1.61^b (3.76)

3.05

Others

thioredoxin domain containing 16

XM_001072487

Txndc16

0.85 (0.31)

0.015

1.80

−0.72 (0.32)

−1.65

0.51 (0.32)

1.42