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Table 2 Genes significantly down-regulated in diabetes vehicle-treated vs. control vehicle-treated group on DNA microarray

From: The effect of a preparation of minerals, vitamins and trace elements on the cardiac gene expression pattern in male diabetic rats

   

Diabetes Vehicle

Diabetes MVT

Control MVT

vs.

vs.

vs.

Control Vehicle

Diabetes Vehicle

Control Vehicle

Gene function

Gene Name provided by RGD a

Acc. Number

Gene Symbol

Log2 (SD)

Corr. p

Fold change

Log2 (SD)

Fold Change

Log2 (SD)

Fold Change

Metabolism

UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2

NM_001109492

B3galt2

-1.14 (0.19)

0.003

-2.21

0.80 (0.49)

1.74

-0.16 (0.60)

-1.11

Metabolism

adenylate kinase 4

NM_017135

Ak4

-0.99 (0.49)

0.026

-1.99

0.76 (0.40)

1.70

-0.47 (0.70)

-1.38

Stress response

APEX (apurinic/apyrimidinic) endonuclease 2

NM_001079892

Apex2

-0.94 (0.56)

0.042

-1.92

0.09 (0.26)

1.06

-1.18 (0.63)

-2.26

Apoptosis/necrosis and inflammation

caspase recruitment domain family, member 9

NM_022303

Card9

-2.74 (0.64)

0.003

-6.69

1.82 (0.52)

3.53

-1.20b (0.88)

-2.29

Apoptosis/necrosis and inflammation

chemokine (C-X-C motif) ligand 12

NM_001033883

Cxcl12

-0.86 (0.38)

0.021

-1.82

0.48 (0.40)

1.40

0.06 (0.30)

1.04

Cell growth and differentiation

neuronal regeneration related protein

NM_178096

Nrep

-1.11 (0.55)

0.023

-2.46

0.50 (0.49)

1.41

-1.46b (1.36)

-2.74

Cell growth and differentiation

HOP homeobox

NM_133621

Hopx

-1.14 (0.52)

0.020

-2.20

0.60 (0.49)

1.51

-0.28 (0.71)

-1.21

Cell growth and differentiation

fibroblast growth factor 18

NM_019199

Fgf18

-1.12 (0.53)

0.021

-2.17

0.80 (0.57)

1.74

-0.51 (0.23)

-1.43

Cell growth and differentiation

ret proto-oncogene

NM_012643

Ret

-1.04 (0.14)

0.003

-2.06

0.63 (0.39)

1.55

-0.63 (0.15)

-1.55

Cell growth and differentiation

G0/G1 switch 2

NM_001009632

G0s2

-0.86 (0.21)

0.007

-1.82

0.58 (0.47)

1.50

0.26 (0.91)

1.20

Receptors and ion channels

adrenoceptor alpha 1D

NM_024483

Adra1d

-1.21 (0.52)

0.016

-2.31

1.12 (0.40)

2.17

-1.03b (1.36)

-2.04

Receptors and ion channels

FXYD domain-containing ion transport regulator 3

NM_172317

Fxyd3

-1.01 (0.49)

0.023

-2.01

1.97 (0.48)

3.92

-0.36 (0.85)

-1.29

Receptors and ion channels

sodium channel, voltage-gated, type IV, beta

NM_001008880

Scn4b

-0.94 (0.30)

0.011

-1.92

0.38 (0.15)

1.30

-0.43 (0.49)

-1.35

Receptors and ion channels

transferrin receptor

NM_022712

Tfrc

-0.87 (0.21)

0.007

-1.83

0.09 (0.20)

1.06

-0.55 (0.32)

-1.46

Structural protein, cell adhesion

myosin binding protein C, fast-type

NM_001106257

Mybpc2

-0.93 (0.47)

0.026

-1.90

0.33 (0.52)

1.25

0.48 (0.82)

1.40

Structural protein, cell adhesion

protocadherin 17

NM_001107279

Pcdh17

-0.94 (0.44)

0.023

-1.91

0.90 (0.43)

1.86

-0.65 (0.43)

-1.57

Hormones

inhibin alpha

NM_012590

Inha

-0.89 (0.39)

0.020

-1.85

1.59 (0.79)

3.01

0.66 (0.21)

1.58

Transport

globin, alpha

NM_001013853

LOC287167

-1.64 (0.72)

0.015

-3.12

-0.23 (0.81)

-1.18

-1.80 (0.76)

-3.47

Transport

haemoglobin, beta adult major chain

NM_198776

Hbb-b1

-1.94 (0.75)

0.011

-3.83

-0.40 (0.77)

-1.32

-2.23 (0.76)

-4.71

Transport

alpha-2u globulin PGCL5

NM_147213

LOC259245

-0.87 (0.54)

0.047

-1.83

-0.03 (0.48)

-1.02

-0.12 (0.58)

-1.08

Others

uncharacterized LOC100909684

XR_146107

LOC10099684

-3.07 (1.43)

0.016

-8.43

2.55 (1.40)

5.85

-0.42 (0.76)

-1.34

Others

uncharacterized LOC100910110

XR_146304

LOC100910110

-1.94 (0.32)

0.003

-3.85

2.32 (0.31)

5.01

-0.46 (1.57)

-1.38

  1. Values show gene expression. Log2 ratio reaching at least ±0.85 and p < 0.05 were considered as significant alterations
  2. aRGD: rat genome database
  3. bnon significant change (p > 0.05)