Fig. 5
From: Diet-induced pre-diabetes slows cardiac conductance and promotes arrhythmogenesis
Whole-cell voltage-clamp K+ current recordings in acutely isolated ventricular cardiomyocytes. Representative recordings from control (a) and Fructose-fat fed rat (FFFR) (b) ventricular cardiomyocytes. c Sustained current density measured at the end of the voltage protocol (as indicated by the black arrow on the inserted protocol) as a function of voltage. (Control cells n = 17, FFFR cells n = 19). d Transient current density determined as the peak current density (measured at the start of the voltage protocol as indicated by the grey arrow) subtracted sustained current density. Control cells n = 17, FFFR cells n = 19. e Steady state inactivating control. Currents recorded at the +20 mV were normalized to maximal current, n = 16, FFFR, n = 19. f Time dependent recovery from inactivation was determined by a two-step protocol with increasing interpulse intervals, control n = 11, FFFR n = 19. Data are based on cells from 5 FFFR and 6 control hearts and presented as mean ± SEM, *p < 0.05