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Fig. 1 | Cardiovascular Diabetology

Fig. 1

From: Rivaroxaban, a factor Xa inhibitor, improves neovascularization in the ischemic hindlimb of streptozotocin-induced diabetic mice

Fig. 1

Effects of rivaroxaban on blood flow recovery and new vessel formation in STZ-induced diabetic mice after hind limb ischemia. a Representative results of laser Doppler measurements pre-operatively and 5 weeks after hind limb ischemia surgery in non-diabetic control mice, diabetic control mice, diabetic mice treatment with low-dose rivaroxaban, and diabetic mice with high-dose rivaroxaban. Color scale illustrates blood flow variation from minimal (dark blue) to maximal (red) values. Arrows indicate ischemic limb after hind limb ischemia surgery. b Endothelial progenitor cell (EPC; defined as Sca-1+/Flk-1+ cells) mobilization after tissue ischemia was determined by flow cytometry in mice. (*P < 0.05 compared with baseline; n = 6). c Mice were sacrificed 5 weeks after surgery and capillaries in the ischemic muscles were visualized by anti-CD31 immunostaining. Results are the mean ± standard error of mean (SEM). (*P < 0.05 compared with DM control; n = 6)

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Cardiovascular Diabetology

ISSN: 1475-2840