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Table 6 Changes in hemodynamic and echocardiographic parameters in the sitagliptin and voglibose group

From: Comparison of effects of sitagliptin and voglibose on left ventricular diastolic dysfunction in patients with type 2 diabetes: results of the 3D trial

Variable Sitagliptin Voglibose Between-group difference
  Mean ± SD P value Mean ± SD P value P value
SBP, mmHg      
Baseline at 0W 135 ± 16   131 ± 13   0.180
At 24W 128 ± 10   129 ± 15   0.855
24W-0W -7 ± 17 0.022 -2 ± 15 0.496 0.184
DBP, mmHg      
Baseline at 0W 74 ± 13   75 ± 10   0.818
At 24W 71 ± 10   75 ± 11   0.108
24W-0W -2 ± 14 0.344 1 ± 10 0.779 0.349
Pulse, b.p.m.      
Baseline at 0W 71 ± 11   71 ± 10   0.903
At 24W 69 ± 12   71 ± 11   0.483
24W-0W -1 ± 12 0.653 0 ± 12 0.816 0.625
Body weight      
Baseline at 0W 69 ± 10   67 ± 12   0.294
At 24W 68 ± 11   67 ± 13   0.736
24W-0W -1.3 ± 3.2 0.018 0.4 ± 2.8 0.433 0.020
a’, cm/s      
Baseline at 0W 8.4 ± 1.6   9.0 ± 1.6   0.110
At 24W 8.1 ± 1.8   9.0 ± 1.6   0.031
24W-0W -0.3 ± 1.7 0.316 0.2 ± 1.4 0.468 0.214
s’, cm/s      
Baseline at 0W 6.6 ± 1.1   7.2 ± 1.2   0.019
At 24W 6.8 ± 1.4   7.0 ± 1.1   0.609
24W-0W 0.2 ± 1.4 0.398 -0.2 ± 1.4 0.412 0.237
Dct      
Baseline at 0W 234 ± 41   237 ± 39   0.769
At 24W 236 ± 42   233 ± 43   0.765
24W-0W 1 ± 41 0.885 -4 ± 35 0.525 0.604
E velocity, m/s      
Baseline at 0W 68 ± 16   62 ± 11   0.048
At 24W 69 ± 14   63 ± 14   0.047
24W-0W 1 ± 10 0.569 0 ± 12 0.879 0.803
A velocity, m/s      
Baseline at 0W 82 ± 19   79 ± 18   0.421
At 24W 80 ± 19   74 ± 14   0.150
24W-0W -1 ± 13 0.537 -4 ± 10 0.020 0.299
E/A ratio      
Baseline at 0W 0.9 ± 0.3   0.8 ± 0.2   0.424
At 24W 0.9 ± 0.2   0.9 ± 0.3   0.668
24W-0W 0.0 ± 0.2 0.402 0.0 ± 0.2 0.157 0.651
Septal thickness, mm      
Baseline at 0W 1.0 ± 0.2   0.9 ± 0.1   0.069
At 24W 0.9 ± 0.1   0.9 ± 0.1   0.502
24W-0W 0.0 ± 0.1 0.015 0.0 ± 0.1 0.876 0.083
LVEF, %      
Baseline at 0W 68 ± 7   71 ± 7   0.209
At 24W 68 ± 6   66 ± 9   0.179
24W-0W 0 ± 8 0.967 -5 ± 8 0.001 0.013
LVMI, g/m2      
Baseline at 0W 93 ± 20   85 ± 18   0.085
At 24W 90 ± 17   86 ± 18   0.239
24W-0W -3 ± 13 0.195 1 ± 14 0.551 0.183
LA volume index, ml/m2      
Baseline at 0W 27.7 ± 5.9   26.1 ± 7.6   0.346
At 24W 27.7 ± 7.5   26.6 ± 6.3   0.508
24W-0W 0.3 ± 5.0 0.734 0.8 ± 5.6 0.448 0.733
Urine albumin, mg/g/Cr      
Baseline at 0W 37 ± 66   31 ± 41   0.603
At 24W 39 ± 94   28 ± 50   0.533
24W-0W -1 ± 50 0.889 -5 ± 30 0.339 0.723
BUN      
Baseline at 0W 17 ± 5   16 ± 5   0.760
At 24W 16 ± 3   16 ± 4   0.824
24W-0W 0 ± 3 0.759 0 ± 4 0.740 0.959