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Table 5 Changes in secondary efficacy measures in the sitagliptin and voglibose group

From: Comparison of effects of sitagliptin and voglibose on left ventricular diastolic dysfunction in patients with type 2 diabetes: results of the 3D trial

Variable Sitagliptin Voglibose Between-group difference
  Mean ± SD P value Mean ± SD P value P value
Glucose      
Baseline at 0W 145 ± 58   133 ± 42   0.304
At 24W 127 ± 26   133 ± 27   0.354
24W-0W -23 ± 60 0.047 1 ± 43 0.916 0.083
HbA1c      
Baseline at 0W 7.1 ± 0.7   6.9 ± 0.5   0.273
At 24W 6.4 ± 0.4   6.7 ± 0.5   0.026
24W-0W -0.7 ± 0.6 <0.0001 -0.3 ± 0.4 0.0004 0.002
GIP      
Baseline at 0W 191 ± 214   159 ± 211   0.517
At 24W 149 ± 161   162 ± 148   0.759
24W-0W -21 ± 226 0.314 0.6 ± 1.6 0.041 0.749
CD34      
Baseline at 0W 1.1 ± 0.7   0.9 ± 0.6   0.239
At 24W 1.1 ± 0.5   0.9 ± 0.7   0.160
24W-0W 0.1 ± 0.5 0.435 0.0 ± 0.5 0.772 0.430
Total cholesterol      
Baseline at 0W 184 ± 27   185 ± 33   0.944
At 24W 178 ± 29   183 ± 37   0.522
24W-0W -3 ± 30 0.603 0 ± 29 0.991 0.709
Triglyceride      
Baseline at 0W 155 ± 107   141 ± 74   0.486
At 24W 132 ± 62   127 ± 72   0.803
24W-0W -15 ± 94 0.391 -13 ± 52 0.190 0.905
HDL-C      
Baseline at 0W 51 ± 12   56 ± 16   0.106
At 24W 52 ± 14   53 ± 15   0.930
24W-0W 0.8 ± 7.9 0.551 -3.6 ± 8.2 0.010 0.021
Adiponectin      
Baseline at 0W 11.0 ± 8.3   13.3 ± 8.7   0.222
At 24W 11.7 ± 8.8   12.9 ± 7.3   0.528
24W-0W 0.5 ± 1.8 0.092 -0.3 ± 2.9 0.539 0.150
MDA-LDL      
Baseline at 0W 106 ± 34   110 ± 37   0.658
At 24W 113 ± 34   109 ± 36   0.591
24W-0W 9 ± 32 0.118 1 ± 38 0.860 0.364
8-OHdG      
Baseline at 0W 11.7 ± 7.9   13.5 ± 10.0   0.392
At 24W 11.4 ± 7.4   14.8 ± 14.6   0.221
24W-0W -0.2 ± 10.0 0.903 1.5 ± 16.9 0.596 0.605
hs-CRP      
Baseline at 0W 3869 ± 9072   1358 ± 2511   0.099
At 24W 1933 ± 5101   661 ± 691   0.147
24W-0W -1929 ± 6798 0.098 -380 ± 1186 0.059 0.186
PTX-3      
Baseline at 0W 1.8 ± 1.0   2.4 ± 2.7   0.206
At 24W 1.5 ± 0.8   1.6 ± 0.8   0.557
24W-0W -0.3 ± 0.7 0.006 -0.3 ± 1.2 0.104 0.974
e-GFR      
Baseline at 0W 75 ± 22   71 ± 15   0.304
At 24W 69 ± 19   72 ± 16   0.411
24W-0W -5 ± 12 0.014 0 ± 9 0.903 0.036
BNP, pg/ml      
Baseline at 0W 39 ± 48   34 ± 35   0.600
At 24W 40 ± 41   28 ± 24   0.160
24W-0W 1 ± 40 0.923 -5 ± 22 0.164 0.443
  1. GIP gastric inhibitory peptide, GLP-1 glucagon-like peptide-1, CD34 C-peptide, MDA-LDL malondialdehyde-modified low density lipoprotein, 8-OHdG 8-hydroxy-2′-deoxyguanosine, hs-CRP high-sensitive C-reactive protein, PTX-3pentraxin-3, eGFR estimated glomerular filtration rate, BNP B-type natriuretic peptide