Table 4 Multivariate analysis of factors related to changes from baseline to week 24 in e’ and E/e’ ratio levels^a

Model1—Primary model

0.500

0.609

Baseline

0.525 (0.309 to 0.742)

<.0001

0.615 (0.471 to 0.758)

<.0001

Sitagliptin/Voglibose

-0.047 (-0.455 to 0.362)

0.8206

0.688 (-0.239 to 1.615)

0.1436

Age—yr

-0.028 (-0.054 to -0.003)

0.0317

0.024 (-0.025 to 0.072)

0.3335

Without/with TZD

0.547 (0.130 to 0.965)

0.0109

-1.411 (-2.339 to -0.483)

0.0034

Model2—Add demographic values^b

0.522

0.641

Baseline

0.520 (0.298 to 0.742)

<.0001

0.603 (0.456 to 0.750)

<.0001

Sitagliptin/Voglibose

-0.069 (-0.504 to 0.365)

0.7509

0.683 (-0.271 to 1.636)

0.1576

Age—yr

-0.025 (-0.052 to 0.002)

0.0739

0.013 (-0.037 to 0.064)

0.5964

Female/Male

0.243 (-0.195 to 0.681)

0.2718

-1.114 (-2.092 to -0.137)

0.0261

BMI (0W)

0.033 (-0.019 to 0.084)

0.2140

-0.037 (-0.155 to 0.081)

0.5306

SBP (0W)

-0.005 (-0.020 to 0.011)

0.5454

-0.002 (-0.036 to 0.031)

0.8917

Pulse (0W)

-0.003 (-0.025 to 0.019)

0.7882

0.022 (-0.028 to 0.071)

0.3911

Without/with TZD

0.662 (0.216 to 1.108)

0.0042

-1.732 (-2.711 to -0.753)

0.0007

Model3—Add complications^b

0.518

0.626

Baseline

0.487 (0.253 to 0.721)

<.0001

0.584 (0.425 to 0.744)

<.0001

Sitagliptin/Voglibose

0.018 (-0.426 to 0.462)

0.9362

0.642 (-0.331 to 1.615)

0.1922

Age—yr

-0.031 (-0.057 to -0.004)

0.0228

0.030 (-0.020 to 0.081)

0.2389

Diabetes complication

-0.395 (-1.038 to 0.247)

0.2238

0.721 (-0.799 to 2.241)

0.3473

Hypertension

0.202 (-0.410 to 0.814)

0.5131

-0.527 (-1.908 to 0.854)

0.4491

Hyperlipidemia

0.219 (-0.317 to 0.755)

0.4177

-0.886 (-2.086 to 0.313)

0.1450

Renal disturbance

-0.219 (-1.000 to 0.562)

0.5780

0.277 (-1.453 to 2.007)

0.7502

Without/with TZD

0.511 (0.068 to 0.954)

0.0244

-1.302 (-2.271 to -0.334)

0.0092

Model4—Add laboratory values^b

0.525

0.642

Baseline

0.542 (0.314 to 0.770)

<.0001

0.615 (0.469 to 0.761)

<.0001

Sitagliptin/Voglibose

-0.127 (-0.568 to 0.314)

0.5671

0.669 (-0.314 to 1.651)

0.1790

Age—yr

-0.023 (-0.053 to 0.006)

0.1220

0.029 (-0.027 to 0.084)

0.3045

WBC (0W)

-0.000 (-0.000 to 0.000)

0.7030

0.000 (-0.000 to 0.000)

0.2013

AST (0W)

0.012 (-0.008 to 0.032)

0.2398

0.003 (-0.040 to 0.046)

0.8871

BUN (0W)

0.009 (-0.045 to 0.063)

0.7380

-0.019 (-0.139 to 0.101)

0.7498

Glucagon (0W)

-0.001 (-0.012 to 0.010)

0.8296

-0.010 (-0.034 to 0.014)

0.3929

Adiponectin (0W)

-0.017 (-0.049 to 0.016)

0.3067

-0.030 (-0.102 to 0.041)

0.4020

IVSTh (0W)

-0.192 (-1.847 to 1.463)

0.8175

-1.323 (-5.000 to 2.353)

0.4749

Without/with TZD

0.380 (-0.181 to 0.941)

0.1808

-1.675 (-2.916 to -0.434)

0.0089

Model5—Add adiponectin^c

0.511

0.620

Baseline

0.516 (0.299 to 0.732)

<.0001

0.623 (0.480 to 0.766)

<.0001

Sitagliptin/Voglibose

-0.080 (-0.490 to 0.330)

0.6991

0.587 (-0.344 to 1.519)

0.2129

Age—yr

-0.025 (-0.051 to 0.001)

0.0637

0.033 (-0.016 to 0.083)

0.1858

Adiponectin (0W)

-0.018 (-0.047 to 0.011)

0.2169

-0.046 (-0.112 to 0.019)

0.1610

Without/with TZD

0.388 (-0.099 to 0.876)

0.1169

-1.807 (-2.884 to -0.730)

0.0013

Model6—Remove TZD

0.493

0.560

Baseline

0.480 (0.266 to 0.695)

<.0001

0.624 (0.472 to 0.777)

<.0001

Sitagliptin/Voglibose

-0.067 (-0.481 to 0.347)

0.7471

0.566 (-0.429 to 1.561)

0.2605

Age—yr

-0.026 (-0.052 to 0.001)

0.0580

0.025 (-0.028 to 0.078)

0.3505

Adiponectin (0W)

-0.030 (-0.055 to -0.005)

0.0187

0.010 (-0.050 to 0.070)

0.7331