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Table 1 Baseline clinical characteristics

From: Comparison of effects of sitagliptin and voglibose on left ventricular diastolic dysfunction in patients with type 2 diabetes: results of the 3D trial

Variable Sitagliptin n = 40 Voglibose n = 40 P value
Age, y 67.8 ± 10.5 66.7 ± 9.8 0.654
Women, n (%) 20(50) 14(35) 0.258
Diabetes duration, months (95 % CI) 48(6-240) 38.5(3-218) 0.145
Body mass index, kg/m2 27.7 ± 4.1 25.7 ± 4.3 0.038
Abdominal girth, cm 88.7 ± 14.3 85.9 ± 15.6 0.469
Current smoking 6(15) 4(10) 0.762
Regular alcohol drinkers 13(33) 17(43) 0.489
NYHA functional class    
Class I, n (%) 17(43) 17(43) 1.000
Class II, n (%) 23(58) 22(55)  
Class III, n (%) 0(0) 1(3)  
Grades of Diastolic Dysfunction    
0 1 (2.6) 3 (7.5) 0.0987
1 31 (79.5) 34 (85.0)  
2 7 (17.9) 3 (7.5)  
Diabetes complication+ 7(18) 3(8) 0.311
Diabetic retinopathy 4(10) 2(5) 0.675
Diabetic nephropathy 3(8) 0(0) 0.241
Diabetic neuropathy 2(5) 0(0) 0.494
Hypertension 37(93) 32(80) 0.193
Hyperuricemia 31(78) 31(78) 1.000
Hyperlipidemia 5(13) 4(10) 1.000
Renal disturbance 7(18) 1(3) 0.057
Mean eGFR 74.8 ± 21.7 70.5 ± 15.3 0.304
Cerebrovascular disease 3(8) 1(3) 0.615
Myocardial infarction 5(13) 2(5) 0.432
Peripheral artery disease 3(8) 1(3) 0.615
Anti-diabetic drugs    
Pioglitazone 14(35) 18(45) 0.494
Sulfonylurea 6(15) 3(8) 0.481
Metformin 7(18) 1(3) 0.057
α-GI 1(3) 0(0) 1.000
Antihypertensive drugs    
ARB 28(70) 27(68) 1.000
Calcium channel blocker 26(65) 22(55) 0.494
Diuretics 15(38) 10(25) 0.335
Others 11(28) 10(25) 1.000
ACE-I 2(5) 3(8)  
α-blocker 4(10) 1(3)  
β-blocker 6(15) 4(10)  
αβ-blocker 1(3) 1(3)  
Aldosterone antagonist 2(5) 1(3)  
Antihyperlipidemic drugs    
Statins 24(60) 22(55) 0.821
Fibrate 2(5) 2(5) 1.000
Ezetimibe 5(13) 6(15) 1.000
Eicosapentaenoic acid 5(13) 2(5) 0.432
Antiplatelet agent 10(25) 12(30) 0.803
Nitrates 1(3) 1(3) 1.000
Allopurinol 1(3) 4(10) 0.359
Uricosuric agents 0(0) 1(3) 1.000
  1. Values are means ± SD, number of patients (%), or median (95 % confidencel Interval). The continuous variables were compared using Student’s t-test, the categorical variables were compared using Fisher’s exact test, grades of diastolic dysfunction was compared using Cochran-Armitage trend test, and the duration of diabetes was compared using the Wilcoxon rank sum test