Skip to main content

Table 2 Lipid profiles in DPP participants by treatment group at baseline and one-year follow-up

From: Differential response in levels of high-density lipoprotein cholesterol to one-year metformin treatment in prediabetic patients by race/ethnicity

Group N (female) Variable Baseline Year 1 Delta P valuea
Metformin 985 (650) TRIG 157.02 ± 86.87 152.59 ± 90.99 −5.01 ± 67.09 0.023
CHOL 202.96 ± 35.25 198.50 ± 34.88 −4.62 ± 25.18 <0.001
HDL-C 46.17 ± 11.58 46.88 ± 12.07 0.67 ± 6.49 0.002
VLDL 31.26 ± 16.93 30.40 ± 17.85 −0.98 ± 13.45 0.027
CLDL 125.05 ± 32.06 120.79 ± 31.14 −4.27 ± 23.08 <0.001
LDLB 69.58 ± 17.67 67.97 ± 17.49 −1.59 ± 13.86 <0.001
LDLC 107.67 ± 27.08 103.92 ± 26.95 −3.65 ± 20.98 <0.001
LDLZ 0.27 ± 0.03 0.27 ± 0.03 0.00 ± 0.02 0.761
Placebo 973 (675) TRIG 167.96 ± 93.87 159.07 ± 95.36 −9.25 ± 73.84 <0.001
CHOL 203.62 ± 36.35 199.67 ± 35.07 −4.04 ± 26.64 <0.001
HDL-C 44.79 ± 11.51 44.78 ± 11.41 −0.09 ± 6.05 0.639
VLDL 33.31 ± 17.73 31.66 ± 18.47 −1.70 ± 13.97 <0.001
CLDL 125.04 ± 33.47 122.76 ± 31.21 −2.22 ± 24.67 0.006
LDLB 69.56 ± 18.38 68.44 ± 17.36 −1.15 ± 13.51 0.01
LDLC 106.48 ± 28.38 103.78 ± 27.04 −2.65 ± 21.51 <0.001
LDLZ 0.26 ± 0.03 0.26 ± 0.03 0.00 ± 0.03 0.830
  1. CHOL, cholesterol; HDL-C, high density lipoprotein cholesterol; LDL, low density lipoprotein cholesterol; LDLB, LDL-B sub-fraction; LDLC, LDL-C sub-fraction; LDLZ, LDL particle size; TRIG, triglycerides; VLDL, very low density lipoprotein cholesterol. Data are presented as mean ± SD
  2. a Paired Student t test for difference between baseline and year-one values. The original abbreviations in the DPP dataset were adopted