Differential response in levels of high-density lipoprotein cholesterol to one-year metformin treatment in prediabetic patients by race/ethnicity

Table 2 Lipid profiles in DPP participants by treatment group at baseline and one-year follow-up

Group	N (female)	Variable	Baseline	Year 1	Delta	P value^a
Metformin	985 (650)	TRIG	157.02 ± 86.87	152.59 ± 90.99	−5.01 ± 67.09	0.023
		CHOL	202.96 ± 35.25	198.50 ± 34.88	−4.62 ± 25.18	<0.001
		HDL-C	46.17 ± 11.58	46.88 ± 12.07	0.67 ± 6.49	0.002
		VLDL	31.26 ± 16.93	30.40 ± 17.85	−0.98 ± 13.45	0.027
		CLDL	125.05 ± 32.06	120.79 ± 31.14	−4.27 ± 23.08	<0.001
		LDLB	69.58 ± 17.67	67.97 ± 17.49	−1.59 ± 13.86	<0.001
		LDLC	107.67 ± 27.08	103.92 ± 26.95	−3.65 ± 20.98	<0.001
		LDLZ	0.27 ± 0.03	0.27 ± 0.03	0.00 ± 0.02	0.761
Placebo	973 (675)	TRIG	167.96 ± 93.87	159.07 ± 95.36	−9.25 ± 73.84	<0.001
		CHOL	203.62 ± 36.35	199.67 ± 35.07	−4.04 ± 26.64	<0.001
		HDL-C	44.79 ± 11.51	44.78 ± 11.41	−0.09 ± 6.05	0.639
		VLDL	33.31 ± 17.73	31.66 ± 18.47	−1.70 ± 13.97	<0.001
		CLDL	125.04 ± 33.47	122.76 ± 31.21	−2.22 ± 24.67	0.006
		LDLB	69.56 ± 18.38	68.44 ± 17.36	−1.15 ± 13.51	0.01
		LDLC	106.48 ± 28.38	103.78 ± 27.04	−2.65 ± 21.51	<0.001
		LDLZ	0.26 ± 0.03	0.26 ± 0.03	0.00 ± 0.03	0.830

CHOL, cholesterol; HDL-C, high density lipoprotein cholesterol; LDL, low density lipoprotein cholesterol; LDLB, LDL-B sub-fraction; LDLC, LDL-C sub-fraction; LDLZ, LDL particle size; TRIG, triglycerides; VLDL, very low density lipoprotein cholesterol. Data are presented as mean ± SD
^a Paired Student t test for difference between baseline and year-one values. The original abbreviations in the DPP dataset were adopted

ISSN: 1475-2840