Cardiospecific CD36 suppression by lentivirus-mediated RNA interference prevents cardiac hypertrophy and systolic dysfunction in high-fat-diet induced obese mice

Table 2 Echocardiographic and electrocardiographic parameters

Phenotypic variables	N-mock	N-CD36	O-mock	O-CD36
Heart rate (bpm)	488.75 ± 31.01	495.25 ± 14.35	443.75 ± 52.31	446.25 ± 36.69
LVEDd (mm)	3.89 ± 0.12	3.91 ± 0.18	4.07 ± 0.12^*a	3.86 ± 0.09^b
LVESd (mm)	2.43 ± 0.19	2.40 ± 0.22	2.63 ± 0.12^*a	2.48 ± 0.07
LVPWd (mm)	0.67 ± 0.03	0.67 ± 0.06	0.70 ± 0.04	0.68 ± 0.02
LVPWs (mm)	1.08 ± 0.05	1.08 ± 0.05	1.13 ± 0.05	1.13 ± 0.05
Ejection fraction (%)	74.75 ± 3.54	75.38 ± 1.60	70.25 ± 1.58^*a	72.88 ± 2.36^b
Fractional shortening (%)	37.75 ± 2.76	38.00 ± 1.07	34.25 ± 0.89^*a	36.38 ± 1.30^b
QRS-complex width (ms)	10.30 ± 0.67	9.60 ± 0.70	10.17 ± 0.72	9.75 ± 0.62

Values are mean ± SD, N = 8-12 for each group
LVEDd left ventricular end-diastolic diameter, LVESd left ventricular end-systolic diameter, LVPWd left ventricular posterior wall thickness at end-diastole, LVPWs left ventricular posterior wall thickness at end-systole
^a P < 0.05 vs. N-CD36
^b P < 0.05 vs. O-mock
^* P < 0.05 vs. N-mock

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