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Fig. 5 | Cardiovascular Diabetology

Fig. 5

From: Cardiospecific CD36 suppression by lentivirus-mediated RNA interference prevents cardiac hypertrophy and systolic dysfunction in high-fat-diet induced obese mice

Fig. 5

HFD feeding resulted in excessive myocardial lipid accumulation that was prevented by CD36 inhibition. a Representative images of myocardial staining for oil red O, a marker of neutral lipid. Red droplets indicate neutral lipid staining (scale bar indicates 50 μm). b Quantification of natural lipid revealed significant increase in lipid accumulation in mice hearts from O-mock compared to all other groups. Inhibition of cardiac CD36 abrogated the increase in lipid accumulation. Values are mean ± SD, three pictures of each mouse were analyzed and N = 3–5 for each group. a, vs. N-mock; b, vs. N-CD36; c, vs. O-mock; (*) P < 0.05

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Cardiovascular Diabetology

ISSN: 1475-2840