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Table 5 Ordinary logistic regression analysis for the associations between parameters of glycemic variability and the severity of CAN

From: The association between glycemic variability and diabetic cardiovascular autonomic neuropathy in patients with type 2 diabetes

  CAN score category
  Univariate OR (95 % CI) p value Multivariate OR (95 % CI) p value
Short-term GV     
  SD of glucose 1.03 (1.01–1.06) 0.007 1.02 (0.99–1.05) 0.191
  MAGE 1.01 (1.00–1.02) 0.059 1.01 (0.99–1.02) 0.398
  CV of glucose 1.05 (1.00–1.10) 0.039 1.05 (1.00–1.10) 0.079
Long-term GV     
  SD of HbA1c 13.79 (4.43–42.89) <0.001 15.40 (4.56–52.01) <0.001
  Adjusted SD of HbA1c 18.83 (5.31–66.80) <0.001 17.46 (3.86–79.06) <0.001
  Log CV of HbA1c 29.23 (5.47–156.11) <0.001 27.21 (4.28–172.91) <0.001
  1. CAN scores were categorized into 0–1.5 points (n = 62), 2–2.5 points (n = 33), and 3–5 points (n = 15)
  2. Multivariate model was adjusted for age, sex, duration of diabetes, mean HbA1c, use of insulin, use of oral anti-diabetic drug, use of aspirin, use of beta-blocker, use of ARB/ACE inhibitor and smoking status
  3. CAN cardiovascular autonomic neuropathy, SD standard deviation, MAGE mean amplitude of glycemic excursions, CV coefficient of variance