|
Long-term GV
|
OR (95 % CI)
|
p value
|
Short-term GV
|
OR (95 % CI)
|
p value
|
|---|
|
SD of HbA1c
| | |
SD of glucose
| | |
|
Crude
|
14.33 (3.45–59.48)
|
<0.001
|
Crude
|
1.04 (1.01–1.07)
|
0.002
|
|
Model 1
|
16.09 (3.55–73.00)
|
<0.001
|
Model 1
|
1.04 (1.01–1.07)
|
0.010
|
|
Model 2
|
9.31 (1.91–45.42)
|
0.028
|
Model 2
|
1.02 (0.99–1.05)
|
0.205
|
|
Model 3
|
12.10 (2.29–63.94)
|
0.003
|
Model 3
|
1.02 (0.99–1.05)
|
0.216
|
|
Adjusted SD of HbA1c
| |
MAGE
| | |
|
Crude
|
21.22 (4.24–106.30)
|
<0.001
|
Crude
|
1.01 (0.99–1.02)
|
0.064
|
|
Model 1
|
23.54 (4.28–129.69)
|
<0.001
|
Model 1
|
1.01 (0.99–1.02)
|
0.145
|
|
Model 2
|
13.39 (2.25–79.82)
|
0.004
|
Model 2
|
1.00 (0.99–1.02)
|
0.676
|
|
Model 3
|
17.02 (2.66–108.86)
|
0.003
|
Model 3
|
1.00 (0.99–1.02)
|
0.781
|
|
Log CV of HbA1c
| |
CV of glucose
| | |
|
Crude
|
19.90 (3.47–113.69)
|
0.001
|
Crude
|
1.07 (1.02–1.12)
|
0.009
|
|
Model 1
|
23.88 (3.77–151.52)
|
0.001
|
Model 1
|
1.07 (1.01–1.13)
|
0.014
|
|
Model 2
|
16.72 (2.43–115.04)
|
0.004
|
Model 2
|
1.06 (1.01–1.13)
|
0.028
|
|
Model 3
|
24.00 (3.09–186.48)
|
0.002
|
Model 3
|
1.07 (1.01–1.13)
|
0.033
|
- Model 1 was adjusted for age, sex and duration of diabetes. Model 2 was additionally adjusted for mean HbA1c over 2 years. Model 3 was additionally adjusted for medication (insulin, oral anti-diabetic drug, aspirin, beta-blocker, ARB/ACE inhibitor) and smoking status
-
CAN cardiovascular autonomic neuropathy, SD standard deviation, MAGE mean amplitude of glycemic excursions, CV coefficient of variance
