The association between glycemic variability and diabetic cardiovascular autonomic neuropathy in patients with type 2 diabetes

Table 3 The comparison of parameters of glycemic variability between hypoglycemic patients with and without cardiovascular autonomic neuropathy

	Over two episodes of hypoglycemia in CGM data (n = 40)
	No CAN (n = 29)	CAN (n = 11)	p value
CGM parameters
SD in glucose (mg/dL)	42.0 ± 14.9	55.0 ± 19.6	0.029
MAGE (mg/dL)	94.5 ± 38.7	105.4 ± 37.7	0.424
CV in glucose (%)	30.5 ± 8.4	35.7 ± 7.2	0.074
Mean glucose in CGM (mg/dL)	137.1 ± 35.2	151.5 ± 38.1	0.264
HbA1c variability
SD of HbA1c (%)	0.4 ± 0.2	0.6 ± 0.3	0.003
Adjusted SD of HbA1c (%)	0.4 ± 0.2	0.6 ± 0.2	0.003
CV of HbA1c	0.05 ± 0.02	0.08 ± 0.03	0.012
Mean HbA1c over 2 years (%)	7.3 ± 1.0	8.2 ± 1.0	0.019

Data are mean ± SD
CAN cardiovascular autonomic neuropathy, CGM continuous glucose monitoring, MAGE mean amplitude of glycemic excursions, SD standard deviation, CV coefficient of variance

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