|
Group
|
Heart
|
Gastrocnemius
|
|---|
|
Interleukin-6 gene expression
|
|
WT + SAL
|
1.5 ± 0.9
|
1.4 ± 0.8
|
|
WT + LPS
|
9.6 ± 3.2p = 0.07
|
61 ± 26*
|
|
iNOS KO + SAL
|
4.1 ± 2.3
|
1.4 ± 0.6
|
|
iNOS KO + LPS
|
19.6 ± 4.7**
|
9.5 ± 0.9***
|
|
Monocyte Chemoattractant Protein-1 (MCP)-1 gene expression
|
|
WT + SAL
|
1.1 ± 0.4
|
1.1 ± 0.3
|
|
WT + LPS
|
2.6 ± 0.1*
|
4.9 ± 2.1
|
|
iNOS KO + SAL
|
1.8 ± 0.7
|
0.6 ± 0.6
|
|
iNOS KO + LPS
|
6.1 ± 2.1 p = 0.07
|
12.1 ± 5.3**
|
- Relative expression (Rq) of Interleukin-6 and Monocyte Chemoattractant Protein-1 (MCP-1) gene measured in tissues excised at the end of a hyperinsulinemic-euglycemic clamp. Data are Rq values relative to the control group (WT + SAL). Data are mean ± SEM. *p < 0.05 vs. WT + SAL; **p < 0.05 vs. iNOS KO + SAL; ***p < 0.05 vs. WT + LPS. iNOS inducible nitric oxide synthase, KO knock-out, LPS lipopolysaccharide, SAL saline, WT wild-type
