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Table 2 Impact of LPS on inflammatory gene expression in WT and iNOS KO mice

From: Tissue inflammation and nitric oxide-mediated alterations in cardiovascular function are major determinants of endotoxin-induced insulin resistance

Group

Heart

Gastrocnemius

Interleukin-6 gene expression

WT + SAL

1.5 ± 0.9

1.4 ± 0.8

WT + LPS

9.6 ± 3.2p = 0.07

61 ± 26*

iNOS KO + SAL

4.1 ± 2.3

1.4 ± 0.6

iNOS KO + LPS

19.6 ± 4.7**

9.5 ± 0.9***

Monocyte Chemoattractant Protein-1 (MCP)-1 gene expression

WT + SAL

1.1 ± 0.4

1.1 ± 0.3

WT + LPS

2.6 ± 0.1*

4.9 ± 2.1

iNOS KO + SAL

1.8 ± 0.7

0.6 ± 0.6

iNOS KO + LPS

6.1 ± 2.1 p = 0.07

12.1 ± 5.3**

  1. Relative expression (Rq) of Interleukin-6 and Monocyte Chemoattractant Protein-1 (MCP-1) gene measured in tissues excised at the end of a hyperinsulinemic-euglycemic clamp. Data are Rq values relative to the control group (WT + SAL). Data are mean ± SEM. *p < 0.05 vs. WT + SAL; **p < 0.05 vs. iNOS KO + SAL; ***p < 0.05 vs. WT + LPS. iNOS inducible nitric oxide synthase, KO knock-out, LPS lipopolysaccharide, SAL saline, WT wild-type