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Table 1 Baseline plasma glucose and insulin concentrations

From: Tissue inflammation and nitric oxide-mediated alterations in cardiovascular function are major determinants of endotoxin-induced insulin resistance

Group Blood glucose (mg/dL) Plasma insulin (ng/ml)
NO Donor vs. Saline
WT + SAL 104 ± 8 1.3 ± 0.4
WT + NO 101 ± 9 0.3 ± 0.1*
LPS vs. Saline; iNOS−/− vs. iNOS+/+ Mice
WT + SAL 96 ± 5 0.7 ± 0.2
WT + LPS 88 ± 6 0.7 ± 0.2
iNOS KO + SAL 96 ± 5 1.0 ± 0.1
iNOS KO + LPS 83 ± 6** 0.7 ± 0.3
  1. All blood and plasma measurements were sampled 10 min before clamp onset (i.e., t = −10 min). Data are presented as mean ± SEM. *p < 0.05 vs. WT + SAL; **p < 0.05 vs. iNOS KO + SAL. iNOS inducible nitric oxide synthase, KO knock-out, LPS lipopolysaccharide, NO nitric oxide donor (sodium nitroprusside), SAL saline, WT wild-type