Tissue inflammation and nitric oxide-mediated alterations in cardiovascular function are major determinants of endotoxin-induced insulin resistance

Table 1 Baseline plasma glucose and insulin concentrations

Group	Blood glucose (mg/dL)	Plasma insulin (ng/ml)
NO Donor vs. Saline
WT + SAL	104 ± 8	1.3 ± 0.4
WT + NO	101 ± 9	0.3 ± 0.1*
LPS vs. Saline; iNOS^−/− vs. iNOS^+/+ Mice
WT + SAL	96 ± 5	0.7 ± 0.2
WT + LPS	88 ± 6	0.7 ± 0.2
iNOS KO + SAL	96 ± 5	1.0 ± 0.1
iNOS KO + LPS	83 ± 6**	0.7 ± 0.3

All blood and plasma measurements were sampled 10 min before clamp onset (i.e., t = −10 min). Data are presented as mean ± SEM. *p < 0.05 vs. WT + SAL; **p < 0.05 vs. iNOS KO + SAL. iNOS inducible nitric oxide synthase, KO knock-out, LPS lipopolysaccharide, NO nitric oxide donor (sodium nitroprusside), SAL saline, WT wild-type

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