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Table 3 Value of apoA-I glycation and serum and HDL-associated PON1, 3 activities in evaluating severity of CAD in type 2 diabetes

From: Association of elevated apoA-I glycation and reduced HDL-associated paraoxonase1, 3 activity, and their interaction with angiographic severity of coronary artery disease in patients with type 2 diabetes mellitus

Activities of paraoxonase Significant CAD Multi-vessel disease High tertile of extent index High tertile of CCSS
AUC (95 % CI) P value AUC (95 % CI) P value AUC (95 % CI) P value AUC (95 % CI) P value
Relative intensity of apoA-I glycation 0.849 (0.792 ~ 0.906) <0.001 0.952 (0.922 ~ 0.981) <0.001 0.855 (0.806 ~ 0.904) <0.001 0.893 (0.843 ~ 0.943) <0.001
Serum PON1 activity 0.617 (0.533 ~ 0.702) 0.008 0.664 (0.590 ~ 0.737) <0.001 0.598 (0.512 ~ 0.684) 0.022 0.599 (0.518 ~ 0.680) 0.021
HDL-associated PON1 activity 0.908 (0.857 ~ 0.960)* <0.001 0.828 (0.774 ~ 0.883)* <0.001 0.824 (0.760 ~ 0.888)* <0.001 0.823 (0.759 ~ 0.887)* <0.001
Serum PON3 activity 0.765 (0.694 ~ 0.837) <0.001 0.777 (0.712 ~ 0.841) <0.001 0.693 (0.618 ~ 0.769) <0.001 0.743 (0.672 ~ 0.814) <0.001
HDL-associated PON3 activity 0.941 (0.909 ~ 0.973)# <0.001 0.939 (0.908 ~ 0.970)# <0.001 0.866 (0.812 ~ 0.921)# <0.001 0.881 (0.835 ~ 0.927)# <0.001
  1. AUC, area under the curve; CAD, coronary artery disease; CCSS, cumulative coronary stenosis score; CI, conficence interval; HDL, high-density lipoprotein; PON, paraoxonase
  2. *P < 0.001 vs. corresponding AUCs of serum PON1 activity; #P < 0.001 vs. corresponding AUCs of serum PON3 activity