Association of elevated apoA-I glycation and reduced HDL-associated paraoxonase1, 3 activity, and their interaction with angiographic severity of coronary artery disease in patients with type 2 diabetes mellitus

Table 3 Value of apoA-I glycation and serum and HDL-associated PON1, 3 activities in evaluating severity of CAD in type 2 diabetes

Activities of paraoxonase	Significant CAD		Multi-vessel disease		High tertile of extent index		High tertile of CCSS
Activities of paraoxonase	AUC (95 % CI)	P value	AUC (95 % CI)	P value	AUC (95 % CI)	P value	AUC (95 % CI)	P value
Relative intensity of apoA-I glycation	0.849 (0.792 ~ 0.906)	<0.001	0.952 (0.922 ~ 0.981)	<0.001	0.855 (0.806 ~ 0.904)	<0.001	0.893 (0.843 ~ 0.943)	<0.001
Serum PON1 activity	0.617 (0.533 ~ 0.702)	0.008	0.664 (0.590 ~ 0.737)	<0.001	0.598 (0.512 ~ 0.684)	0.022	0.599 (0.518 ~ 0.680)	0.021
HDL-associated PON1 activity	0.908 (0.857 ~ 0.960)*	<0.001	0.828 (0.774 ~ 0.883)*	<0.001	0.824 (0.760 ~ 0.888)*	<0.001	0.823 (0.759 ~ 0.887)*	<0.001
Serum PON3 activity	0.765 (0.694 ~ 0.837)	<0.001	0.777 (0.712 ~ 0.841)	<0.001	0.693 (0.618 ~ 0.769)	<0.001	0.743 (0.672 ~ 0.814)	<0.001
HDL-associated PON3 activity	0.941 (0.909 ~ 0.973)#	<0.001	0.939 (0.908 ~ 0.970)#	<0.001	0.866 (0.812 ~ 0.921)#	<0.001	0.881 (0.835 ~ 0.927)#	<0.001

AUC, area under the curve; CAD, coronary artery disease; CCSS, cumulative coronary stenosis score; CI, conficence interval; HDL, high-density lipoprotein; PON, paraoxonase
*P < 0.001 vs. corresponding AUCs of serum PON1 activity; #P < 0.001 vs. corresponding AUCs of serum PON3 activity

ISSN: 1475-2840