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Table 2 Correlation of apoA-I glycation and serum and HDL-associated PON1, 3 activities with the severity of CAD in patients with type 2 diabetes

From: Association of elevated apoA-I glycation and reduced HDL-associated paraoxonase1, 3 activity, and their interaction with angiographic severity of coronary artery disease in patients with type 2 diabetes mellitus

Variables Relative intensity of apoA-I glycation (%) Serum PON1 activity (U/mL) HDL-associated PON1 activity (U/mL) Serum PON3 activity (U/mL) HDL-associated PON3 activity (U/mL)
Diseased vessels      
 0-vessel disease (n = 61) 5.69 ± 1.43 86.01 ± 17.36 92.19 ± 33.43 39.21 ± 6.62 64.58 ± 22.44
 1-vessel disease (n = 41) 5.98 ± 1.08 85.96 ± 17.17 48.12 ± 11.34 35.81 ± 5.20 38.76 ± 12.78
 2-vessel disease (n = 53) 8.17 ± 1.26 79.06 ± 16.10 42.19 ± 14.37 32.51 ± 5.65 22.07 ± 7.58
 3-vessel disease (n = 50) 10.24 ± 1.32 71.67 ± 15.09 35.15 ± 14.94 31.25 ± 5.80 19.88 ± 9.06
 Unadjusted Spearman r 0.800 −0.305 −0.659 −0.500 −0.782
 Unadjusted P for trend <0.001 <0.001 <0.001 <0.001 <0.001
 *Adjusted Spearman r 0.730 −0.345 −0.562 −0.414 −0.691
 *Adjusted P for trend <0.001 <0.001 <0.001 <0.001 <0.001
Extent index
 Unadjusted r 0.627 −0.278 −0.588 −0.358 −0.600
 Unadjusted P <0.001 <0.001 <0.001 <0.001 <0.001
 *Adjusted r 0.546 −0.291 −0.508 −0.296 −0.537
 *Adjusted P <0.001 <0.001 <0.001 <0.001 <0.001
Cumulative coronary stenosis score
 Unadjusted r 0.709 −0.243 −0.572 −0.358 −0.594
 Unadjusted P <0.001 <0.001 <0.001 <0.001 <0.001
 *Adjusted r 0.626 −0.267 −0.453 −0.288 −0.488
 *Adjusted P <0.001 <0.001 <0.001 <0.001 <0.001
  1. Values are means ± SD or Peason corrlation coefficients unless otherwise indicated
  2. CAD, coronary artery disease; HDL, high-density lipoprotein; PON, paraoxonase
  3. *adjusted for gender, age, body mass index, history of hypertension and dyslipidemia, smoking, glycated hemoglobin A1c, estimated glomerular filtration rate, total/HDL cholesterol ratio, high-sentivity C-reactive protein and use of statins