Association of elevated apoA-I glycation and reduced HDL-associated paraoxonase1, 3 activity, and their interaction with angiographic severity of coronary artery disease in patients with type 2 diabetes mellitus

Table 2 Correlation of apoA-I glycation and serum and HDL-associated PON1, 3 activities with the severity of CAD in patients with type 2 diabetes

Variables	Relative intensity of apoA-I glycation (%)	Serum PON1 activity (U/mL)	HDL-associated PON1 activity (U/mL)	Serum PON3 activity (U/mL)	HDL-associated PON3 activity (U/mL)
Diseased vessels
0-vessel disease (n = 61)	5.69 ± 1.43	86.01 ± 17.36	92.19 ± 33.43	39.21 ± 6.62	64.58 ± 22.44
1-vessel disease (n = 41)	5.98 ± 1.08	85.96 ± 17.17	48.12 ± 11.34	35.81 ± 5.20	38.76 ± 12.78
2-vessel disease (n = 53)	8.17 ± 1.26	79.06 ± 16.10	42.19 ± 14.37	32.51 ± 5.65	22.07 ± 7.58
3-vessel disease (n = 50)	10.24 ± 1.32	71.67 ± 15.09	35.15 ± 14.94	31.25 ± 5.80	19.88 ± 9.06
Unadjusted Spearman r	0.800	−0.305	−0.659	−0.500	−0.782
Unadjusted P for trend	<0.001	<0.001	<0.001	<0.001	<0.001
*Adjusted Spearman r	0.730	−0.345	−0.562	−0.414	−0.691
*Adjusted P for trend	<0.001	<0.001	<0.001	<0.001	<0.001
Extent index
Unadjusted r	0.627	−0.278	−0.588	−0.358	−0.600
Unadjusted P	<0.001	<0.001	<0.001	<0.001	<0.001
*Adjusted r	0.546	−0.291	−0.508	−0.296	−0.537
*Adjusted P	<0.001	<0.001	<0.001	<0.001	<0.001
Cumulative coronary stenosis score
Unadjusted r	0.709	−0.243	−0.572	−0.358	−0.594
Unadjusted P	<0.001	<0.001	<0.001	<0.001	<0.001
*Adjusted r	0.626	−0.267	−0.453	−0.288	−0.488
*Adjusted P	<0.001	<0.001	<0.001	<0.001	<0.001

Values are means ± SD or Peason corrlation coefficients unless otherwise indicated
CAD, coronary artery disease; HDL, high-density lipoprotein; PON, paraoxonase
*adjusted for gender, age, body mass index, history of hypertension and dyslipidemia, smoking, glycated hemoglobin A1c, estimated glomerular filtration rate, total/HDL cholesterol ratio, high-sentivity C-reactive protein and use of statins

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