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Fig. 10 | Cardiovascular Diabetology

Fig. 10

From: DPP-4 inhibition with linagliptin ameliorates cognitive impairment and brain atrophy induced by transient cerebral ischemia in type 2 diabetic mice

Fig. 10

Effect of 7 days of linagliptin administration on oxidative stress in cortex and hippocampus, and cerebral gp91phox of db/db mice subjected to transient BCCAO. a indicates representative photomicrograph of DHE-stained cerebral sections. Bar = 100 μm. b and c indicate relative DHE fluorescence in cortex and hippocampus, respectively. d indicates cerebral gp91phox levels corrected to GAPDH. In d, upper panels indicate representative western blot band. Abbreviations used are the same as in Fig. 3. Each value represents mean ± SEM (n = 7 in Sham, n = 6 in BCCAO + Veh, n = 7 in BCCAO + Lin.)

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