Table 3 Overview of additional clinical trials included in evaluation of congestive heart failure (CHF)

1218.2

Linagliptin 1, 2.5, 5, 10 mg Placebo;

35 9

None

<2

Heise et al. [43]. NCT02183350

1218.3

Linagliptin, 2.5, 5, 10 mg Placebo;

61 16

None

4

Forst et al. [44]. NCT 02183415

1218.5

Linagliptin 0.5, 2.5, 5 mg Placebo;

170 67

None

30

Singh-Franco et al. [45]. NCT00328172

1218.6

Linagliptin 1, 5, 10 mg Placebo;

197 71

Metformin (most received ≥1500 mg/d)

12

Forst et al. [46]. NCT00309608

1218.37

Linagliptin 5 mg Placebo;

40 40

None

4

Rauch et al. [47]. NCT00716092

1264.3

Linagliptin 5 mg Pioglitazone 15, 30, 45 mg Linagliptin + pioglitazone;

105 284 274

None

Up to 54

NCT01183013