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Table 1 Overview of linagliptin clinical trials included in the CV safety analysis of adjudicated events

From: Cardiovascular safety of linagliptin in type 2 diabetes: a comprehensive patient-level pooled analysis of prospectively adjudicated cardiovascular events

Study number Treatment Patients Background Follow-up (weeks) Reference/NCT number
1218.15 Linagliptin 5 mg Placebo; 259 130 Pioglitazone 24 Gomis et al. [39]. NCT00641043
1218.16 Linagliptin 5 mg Placebo; 336 167 None 24 Del Prato et al. [40]. NCT00621140
1218.17 Linagliptin 5 mg Placebo; 523 177 Metformin 24 Taskinen et al. [41]. NCT00601250
1218.18 Linagliptin 5 mg Placebo; 792 263 Metformin + sulfonylurea 24 Owens et al. [42]. NCT00602472
1218.20 Linagliptin 5 mg Glimepiride 1–4 mg; 776 775 Metformin 104 NCT00622284
1218.23 Linagliptin 5 mg Linagliptin 10 mg Voglibose 0.6 mg Placebo; 159 160 162 80 None 26 NCT00654381
1218.35 Linagliptin 5 mg Placebo; 157 81 Sulfonylurea 18 NCT00819091
1218.36* Linagliptin 5 mg Placebo; 628 627 Basal insulin ≥52 NCT00954447
1218.43 Linagliptin 5 mg Placebo; 67 63 None 52 NCT00800683
1218.46 Linagliptin 5 mg Placebo; 428 363 Metformin 24 NCT00798161
1218.50 Linagliptin 5 mg Placebo; 151 76 None 52 NCT00740051
1218.52† Linagliptin 5 mg Placebo; 396 170 Metformin 54 NCT00915772
1218.61* Linagliptin 5 mg Placebo; 183 89 Metformin + pioglitazone 24 NCT00996658
1218.62* Linagliptin 5 mg Placebo; 447 44 Metformin 12 NCT01012037
1218.63* Linagliptin 5 mg Placebo; 162 79 None 24 NCT01084005
1218.64* Linagliptin 5 mg Placebo; 113 122 None 52 NCT01087502
1218.65* Linagliptin 5 mg Placebo; 205 100 Metformin 24 NCT01215097
1218.66* Linagliptin 5 mg Placebo; 200 99 None 24 NCT01214239
1218.75* Linagliptin 5 mg Placebo; 101 115 None 24 NCT01194830
  1. *Trials with prospective independent adjudication of hospitalization for CHF.
  2. †Trial 1218.52 is an extension of study 1218.46 and was analyzed in conjunction with 1218.46, and therefore is not displayed as an individual study in other displays. CV, cardiovascular; CHF, congestive heart failure.
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Cardiovascular Diabetology

ISSN: 1475-2840