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Table 1 Baseline patient characteristics amongst all patients

From: Increased plasma BMP-2 levels are associated with atherosclerosis burden and coronary calcification in type 2 diabetic patients

Clinical variables Normal (n = 34) T2DM (n = 26) CAD (n = 31) T2DM + CAD (n = 29) P value
Age, yr 58.0 ± 11 60 ± 2.3 57 ± 2.2 61.6 ± 2.0 0.41
Male Gender, n (%) 21,(61) 20,(77) 21,(68) 20,(61) 0.50
Body mass index, kg/m2 26 ± 2.9 27 ± 3.7 27 ± 4.0 30 ± 3.7 0.07
Hypertension, n (%) 18(56) 21(84) 119(61) 25(76)) 0.08
Dyslipidemia, n (%) 8(25) 5(21) 19(61) 25(76) 0.63
Smoking, n (%) 15(76) 12(48) 15(48) 9(27) 0.23
Blood glucose, mmol/L 5.6 ± 1.1 6.2 ± 2.2 5.5 ± 1.0 7.6 ± 2.8 0.004
Triglycerides, mmol/L 1.7 ± 1.1 2.0 ± 0.3 2.0 ± 0.2 1.9 ± 0.2 0.63
Total cholesterol, mmol/L 4.4 ± 0.2 4.3 ± 0.2 4.4 ± 0.9 4.2 ± 0.2 0.92
Low-density lipoprotein, mmol/L 2.7 ± 0.9 2.7 ± 0.8 2.7 ± 0.3 2.5 ± 0.9 0.62
High-density lipoprotein, mmol/L 1.0 ± 0.04 1.0 ± 0.04 1.0 ± 0.03 0.98 ± 0.04 0.80
Hs CRP, mg/L, Median (Q1, Q3) 1.5(0.7,3.7) 0.64(0.4,1.6) 1.2(0.7,2.9) 1.4(0.7,6.5) <0.001
Cr, μmol/L Median (Q1, Q3) 72(65,85) 76(67,86) 76(66,88) 77(63,84) 0.9
Ejection fraction, % 64 ± 5.7 63 ± 6.7 64 ± 7.3 62.2 ± 6.2 0.8
LVEDD, mm 47 ± 4.9 50.1 ± 4.5 48 ± 5.3 47 ± 4.6 0.20
BMP-2 (pg/mL) 17.1 ± 0.6 19.2 ± 0.3 18.7 ± 0.3 20.1 ± 0.3 P < 0.001
HbA1c (n %) 5.9 ± 1.52 7.3 ± 1.6 5.8 ± 0.7 8.23 ± 1.6 P < 0.001
Medications on admission      
Aspirin, No. (%) 24(71) 18(69) 24(77) 26(78) 0.78
Clopidogrel, No. (%) 13(38) 12(46) 16(52) 20(61) 0.32
Beta-blockers, No. (%) 14(41) 12(48) 14(45) 16(48) 0.93
ACEI/ARB, No. (%) 14(42) 17(71) 16(76) 23(85) 0.0017
Statins, No. (%) 8(23.5) 15(58) 15(48) 22(67) 0.0025
Insulin, No. (%) 0(0) 17(65) 0(0) 23(79) <0.001
Oral hypoglycemics, No. (%) 0(0) 18(69) 0(0) 25(86) <0.001
  1. BMP-2, Bone Morphogenic Protein-2; CAD, Coronary artery disease; HbA1c; Glycosylated hemoglobin A1c; hsCRP, High sensitivity C-reactive protein; LVEDD, Left ventricular end diastolic diameter; Cr, Serum creatinine; T2DM, Type II Diabetes Mellitus.