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Table 5 Association between the risk of DR and the covariates stratified by the GGT1 genotype in the T2DM subjects in the multiple regression model

From: Interactive effects of a common γ-glutamyltransferase 1 variant and low high-density lipoprotein-cholesterol on diabetic macro- and micro-angiopathy

  GGT1 A/A genotype GGT1 A/G or G/G genotype
  HR (95% CI) P -value HR (95% CI) P -value
HbA1c 1.46 (1.23 - 1.73) <0.001 1.17 (0.87 - 1.58) 0.30
Female 3.49 (1.25 - 9.72) 0.02 3.13 (0.74 - 13.33) 0.12
Age 0.94 (0.90 - 0.98) 0.005 1.02 (0.96 - 1.09) 0.49
ALDH2*2 allele 2.21 (0.99 - 4.91) 0.052 7.88 (1.53 - 40.54) 0.014
HDL-C 1.01 (0.99 - 1.04) 0.35 0.94 (0.90 - 0.99) 0.02
Diabetes duration 1.04 (0.97 - 1.11) 0.26 1.11 (1.01 - 1.23) 0.03
GGT 1.00 (0.98 - 1.01) 0.50 1.02 (0.999 - 1.03) 0.07
Hypertension 1.90 (0.74 - 4.90) 0.18 1.86 (0.46 - 7.61) 0.39
Drinking 1.45 (0.54 - 3.89) 0.46 1.89 (0.41 - 8.73) 0.42
ALT 1.00 (0.97 - 1.03) 0.89 0.99 (0.97 - 1.02) 0.56
  1. Bold typeface indicates data that are statistically significant. DR, diabetic retinopathy; GGT, γ-glutamyltransferase; T2DM, type 2 diabetes mellitus; HR, hazard ratio; CI, confidence interval; HbA1c, hemoglobin A1c; ALDH2, aldehyde dehydrogenase 2; HDL-C, high-density lipoprotein cholesterol; ALT, alanine aminotransferase.