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Table 5 Association between the risk of DR and the covariates stratified by the GGT1 genotype in the T2DM subjects in the multiple regression model

From: Interactive effects of a common γ-glutamyltransferase 1 variant and low high-density lipoprotein-cholesterol on diabetic macro- and micro-angiopathy

 

GGT1 A/A genotype

GGT1 A/G or G/G genotype

 

HR (95% CI)

P -value

HR (95% CI)

P -value

HbA1c

1.46 (1.23 - 1.73)

<0.001

1.17 (0.87 - 1.58)

0.30

Female

3.49 (1.25 - 9.72)

0.02

3.13 (0.74 - 13.33)

0.12

Age

0.94 (0.90 - 0.98)

0.005

1.02 (0.96 - 1.09)

0.49

ALDH2*2 allele

2.21 (0.99 - 4.91)

0.052

7.88 (1.53 - 40.54)

0.014

HDL-C

1.01 (0.99 - 1.04)

0.35

0.94 (0.90 - 0.99)

0.02

Diabetes duration

1.04 (0.97 - 1.11)

0.26

1.11 (1.01 - 1.23)

0.03

GGT

1.00 (0.98 - 1.01)

0.50

1.02 (0.999 - 1.03)

0.07

Hypertension

1.90 (0.74 - 4.90)

0.18

1.86 (0.46 - 7.61)

0.39

Drinking

1.45 (0.54 - 3.89)

0.46

1.89 (0.41 - 8.73)

0.42

ALT

1.00 (0.97 - 1.03)

0.89

0.99 (0.97 - 1.02)

0.56

  1. Bold typeface indicates data that are statistically significant. DR, diabetic retinopathy; GGT, γ-glutamyltransferase; T2DM, type 2 diabetes mellitus; HR, hazard ratio; CI, confidence interval; HbA1c, hemoglobin A1c; ALDH2, aldehyde dehydrogenase 2; HDL-C, high-density lipoprotein cholesterol; ALT, alanine aminotransferase.
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Cardiovascular Diabetology

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