Interactive effects of a common γ-glutamyltransferase 1 variant and low high-density lipoprotein-cholesterol on diabetic macro- and micro-angiopathy

Table 4 Interactive effects between the GGT1 genotype and serum HDL-C levels on the baPWV in the T2DM subjects

HDL-C	*GGT1* genotype	High baPWV ^*		baPWV (cm/sec)
HDL-C	*GGT1* genotype	OR ^† (95% CI)	P -value	B ^†	SE	P -value
≥ 1.0 mmol/L	A/A genotype	1	-	0	-	-
	A/G or G/G genotype	1.49 (0.91 - 2.44)	0.11	47.38	38.60	0.22
<1.0 mmol/L	A/A genotype	1.31 (0.73 - 2.35)	0.37	58.32	54.50	0.29
	A/G or G/G genotype	2.49 (1.07 - 5.82)	0.04	150.84	79.19	0.06

Bold typeface indicates data that are statistically significant.
^*baPWV ≥ 1750 cm/sec.
^†Adjusted by age, hypertension, diabetes duration, drinking, ALT level and ALDH2*2 allele.
GGT, γ-glutamyltransferase; HDL-C, high-density lipoprotein cholesterol; baPWV, brachial-ankle pulse wave velocity; T2DM, type 2 diabetes mellitus; OR, odds ratio; CI, confidence interval; B, partial regression coefficient; SE, standard error.

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