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Table 1 Clinical characteristics of T2DM stratified by the GGT1 genotype at baseline
| A/A (n = 219) | A/G (n = 120) | G/G (n = 13) | P -value | |
|---|---|---|---|---|
| Female (%) | 33.3 | 35.0 | 46.2 | 0.61 |
| Age (years) | 59.1 ± 10.5 | 61.6 ± 11.7 | 60.0 ± 10.6 | 0.13 |
| BMI (kg/m2) | 24.3 ± 3.9 | 24.0 ± 3.4 | 24.1 ± 2.9 | 0.72 |
| Diabetes duration (years) | 10.7 ± 8.2 | 10.7 ± 8.8 | 10.8 ± 6.2 | 1.00 |
| HbA1c (%) | 8.4 ± 2.0 | 8.3 ± 2.0 | 8.1 ± 2.0 | 0.66 |
| Systolic BP (mmHg) | 139.5 ± 19.5 | 137.9 ± 21.3 | 143.4 ± 17.2 | 0.57 |
| Diastolic BP (mmHg) | 83.4 ± 11.4 | 81.8 ± 12.9 | 85.9 ± 9.7 | 0.31 |
| Triglycerides (mmol/L) | 1.7 ± 1.2 | 1.9 ± 2.3 | 1.8 ± 1.9 | 0.50 |
| HDL-C (mmol/L) | 1.4 ± 0.4 | 1.4 ± 0.4 | 1.4 ± 0.3 | 1.00 |
| LDL-C (mmol/L) | 3.2 ± 0.8 | 3.2 ± 0.9 | 3.1 ± 0.6 | 0.90 |
| AST (IU/L) | 24.8 ± 9.7 | 27.1 ± 14.2 | 25.2 ± 8.4 | 0.22 |
| ALT (IU/L) | 26.6 ± 16.4 | 30.2 ± 27.2 | 27.7 ± 11.6 | 0.31 |
| GGT (IU/L) | 36.6 ± 33.1 | 42.2 ± 36.8 | 43.6 ± 24.1 | 0.31 |
| Log GGT (IU/L) | 1.47 ± 0.30 | 1.51 ± 0.30 | 1.57 ± 0.26 | 0.08 |
| Hypertension (%) | 60.3 | 59.2 | 76.9 | 0.50 |
| Dyslipidemia (%) | 68.8 | 70.8 | 38.5 | 0.07 |
| Ever smoker (%) | 45.4 | 41.2 | 33.3 | 0.70 |
| Alcohol intake (%) | 51.4 | 46.7 | 38.5 | 0.52 |
| Therapy components | ||||
| Hypoglycemic agents | ||||
| Oral hypoglycemic agents (%) | 64.1 | 65.5 | 53.8 | 0.72 |
| Insulin (%) | 23.0 | 19.3 | 30.8 | 0.52 |
| Antihypertensive agents | ||||
| ACE inhibitors or ARBs(%) | 20.3 | 16.0 | 7.7 | 0.44 |
| Others(%) | 23.5 | 26.9 | 23.1 | 0.77 |
| Agents for hyperlipidemia | ||||
| Fibrates(%) | 0.9 | 0.8 | 7.7 | 0.15 |
| Statins(%) | 8.3 | 6.7 | 0.0 | 0.70 |
| Others (%) | 0.9 | 1.7 | 0.0 | 0.67 |
