-) production (A) and the mRNA expression of nicotinamide adenine dinucleotide phosphate (reduced form, NADPH) oxidase subunits p22phox (B) and gp91phox (C) in the soleus of DS rats. O2
- production and the expression of p22phox and gp91phox were significantly increased in the muscle of hypertensive DS rats, compared with normotensive DS rats. ARB candesartan significantly reduced O2
- production and the mRNA expression of p22phox and gp91phox . *P < 0.05 vs. NS, #p < 0.05 vs. HS; N = 5-7.