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Table 1 Baseline characteristics of subjects according to coronary artery stenosis

From: The amount of C1q–adiponectin complex is higher in the serum and the complex localizes to perivascular areas of fat tissues and the intimal–medial layer of blood vessels of coronary artery disease patients

  Normal (n = 72) Mild to moderate (n = 41) Severe (n = 40) P value
Age (years) 56.4 ± 7.8a 57.4 ± 11.0a 67.0 ± 10.3b <0.001
Sex (male/female) 36/36a 32/9b 31/9b 0.002
Body mass index (kg/m2) 24.9 ± 2.7a,b 25.9 ± 2.5a 24.1 ± 3.4b 0.025
Systolic blood pressure (mmHg) 128.1 ± 13.7 126.5 ± 13.4 125.1 ± 17.7 0.596
Diastolic blood pressure (mmHg) 77.2 ± 10.1a 78.7 ± 9.3a 70.7 ± 10.3b 0.001
Fasting blood glucose (mg/dL) 114.4 ± 32.3a 129.9 ± 42.4a,b 156.4 ± 70.0b 0.001
HbA1c (%) 6.3 ± 1.1a 6.9 ± 1.6a,b 7.0 ± 1.5b 0.018
Total cholesterol (mg/dL) 215.3 ± 31.2a 209.3 ± 39.7a 171.0 ± 49.4b <0.001
Triglycerides (mg/dL) 172.7 ± 99.6 206.2 ± 201.3 147.5 ± 110.9 0.205
HDL-cholesterol (mg/dL) 52.8 ± 12.0a 48.7 ± 12.5a,b 43.4 ± 10.2b <0.001
LDL-cholesterol (mg/dL) 118.7 ± 27.5 120.2 ± 36.5 101.4 ± 37.9 0.039
Aspartate aminotransferase (IU/L) 24.6 ± 11.3a 26.2 ± 8.3a 37.7 ± 22.4b <0.001
Alanine aminotransferase (IU/L) 30.3 ± 21.2 35.5 ± 22.8 29.2 ± 18.3 0.225
Creatinine (mg/dL) 1.0 ± 0.2 1.1 ± 0.2 1.2 ± 0.7 0.265
hs-CRP (mg/dL) 0.1 ± 0.1a 0.6 ± 2.2a,b 2.0 ± 4.5b <0.001
Diabetes mellitus (%) 38.9 48.8 62.5 0.056
Sulfonyl ureas/biguanides/thiazolidinediones/dipeptidyl peptidase-4 inhibitors/insulin (n) 2/6/1/1/0 3/7/2/2/1 8/8/4/2/2 0.912
Hypertension (%) 30.6a 61.0b 75.0b <0.001
Calcium channel blockers/angiotensin receptor blockers/angiotensin-converting-enzyme inhibitor/β-blockers/diuretics (n) 6/5/1/1/1 10/12/2/3/5 12/13/6/4/4 0.934
Dyslipidemia (%) 51.4 63.4 72.5 0.081
Statins/fibrates/ezetimibe (n) 18/3/0 20/4/0 25/5/1 0.821
C1q (μg/ml) 5.77 ± 1.68a 5.38 ± 1.34a 4.13 ± 0.75b <0.001
Total APN (μg/ml) 7.74 ± 4.59 5.89 ± 4.23 6.51 ± 3.95 0.097
HMW-APN (μg/ml) 4.91 ± 3.70a 3.19 ± 2.20a 1.51 ± 0.50b <0.001
C1q/Total APN ratio 1.15 ± 0.98 1.67 ± 1.52 1.00 ± 0.85 0.48
C1q/HMW-APN ratio 2.46 ± 2.52a 2.77 ± 2.33a,b 3.08 ± 1.31b 0.047
  1. Data are presented as the mean ± SD. a,bValues with the same letter did not differ significantly by Bonferroni post hoc analysis or χ 2-tests. Normal, any coronary artery stenosis <25%; mild to moderate, any coronary artery stenosis ≥25%; severe, three coronary artery stenosis ≥50% (coronary artery bypass surgery). HbA1c, glycated hemoglobin; HDL, high-density lipoprotein; LDL, low-density lipoprotein; hs-CRP, high-sensitivity C-reactive protein; APN, adiponectin; HMW-APN, high-molecular weight APN.