| |
LOWER glucose group (<4.5 mmol/l)
|
MEDIUM glucose group (4.5-6.0 mmol/l)
|
HIGHER glucose group (>6.0 mmol/l)
|
P-value
|
|---|
|
Fibrinogen, g/dL
|
3.06 (2.66-3.48)
|
3.13 (2.67-3.57)
|
3.15 (2.64-3.61)
|
0.98
|
|
Peak thrombin, nM
|
273 (209–380)
|
225 (201–268)*
|
236 (196–275)*
|
0.002
|
|
PF4
|
10.6 (9.1-12.8)
|
9.5 (8.2-12.0)
|
10.3 (8.2-12.8)
|
0.26
|
|
sCD40L
|
4.3 (3.6-4.9)
|
3.7 (3.1-4.4)
|
3.8 (3.3-4.8)
|
0.09
|
|
TAFI, %
|
71.5 (41.6-90.0)
|
91.0 (84.0-106.0)*
|
100.0 (92.0-111.0)*
|
<0.0001
|
|
PAI-1: Ag
|
30.6 (25.8-36.1)
|
32.0 (28.7-36.3)
|
33.9 (29.4-38.9)
|
0.23
|
|
Plasminogen, %
|
109 ± 21
|
108 ± 16
|
110 ± 14
|
0.83
|
|
Antiplasmin, %
|
109 (100–118)
|
109 (96–118)
|
107 (97–117)
|
0.61
|
|
Ks, cm2x10−9
|
6.52 ± 0.79
|
7.29 ± 0.81*
|
7.06 ± 0.88*
|
0.0001
|
|
t50%, min
|
10.49 ± 0.97
|
9.55 ± 0.91*
|
9.79 ± 1.11*
|
<0.0001
|
|
Lag_phase, s
|
45 (41–50)
|
44 (41–47.0)
|
43 (40–45)*
|
0.019
|
|
ΔAbsmax, 405 nm
|
0.79 (0.76-0.83)
|
0.81 (0.77-0.86)
|
0.82 (0.80-0.87)*
|
0.015
|
|
D-Drate mg/L/min
|
0.069 ± 0.006
|
0.070 ± 0.005
|
0.07 ± 0.004
|
0.47
|
|
D-Dmax mg/L
|
3.90 (3.78-4.22)
|
3.87 (3.69-4.06)
|
3.88 (3.62-4.22)
|
0.30
|
- Values are given as mean ± SD, median (interquartile range). P value was measured using analysis of variance (ANOVA) with post-hoc Bonferroni test or Kruskal-Wallis test with multiple comparisons of mean rank, *p < 0.05 as compared with LOWER glucose group.
-
Abbreviations: ΔAbsmax, maximum absorbance of fibrin gel at 405 nm determined by using turbidimetry; sCD40L, soluble CD40 ligand; D-Dmax, maximum D-dimer levels in the lysis assay; D-Drate, maximum rate of increase in D-dimer levels in the lysis assay; Ks, permeability coefficient; PAI-1: Ag; plasminogen activator inhibitor-1 antigen; PF4, platelet factor 4; t50%, half-lysis time; TAFI, thrombin-activatable fibrinolysis inhibitor.
