Skip to main content
Figure 2 | Cardiovascular Diabetology

Figure 2

From: Plasma levels of matrix metalloproteinase-2, -3, -10, and tissue inhibitor of metalloproteinase-1 are associated with vascular complications in patients with type 1 diabetes: the EURODIAB Prospective Complications Study

Figure 2

Associations between plasma levels of MMPs, TIMP-1 and microvascular complications. Point estimates and 95% confidence intervals show the difference in plasma levels of lnMMP or TIMP-1 (in SD) in patients with vs. those without microvascular complications resulting from a multivariable regression model including all cardiovascular risk factors and the other vascular complications (model 2). A, differences in micro- (grey bars) or macroalbuminuria (black bars) compared to normoalbuminuria; B, differences in non-proliferative (grey bars) and proliferative retinopathy (black bars) compared to no retinopathy. P-trend indicates the statistical significance of the associations between plasma levels of MMPs or TIMP and the degrees of albuminuria (normo- vs. micro- vs. macroalbuminuria) or retinopathy (no vs. non-proliferative vs. proliferative retinopathy).

Back to article page

Cardiovascular Diabetology

ISSN: 1475-2840