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Table 7 Effects of MK-0626 plus GLP-1 on glucose and insulin

From: Acute hemodynamic and renal effects of glucagon-like peptide 1 analog and dipeptidyl peptidase-4 inhibitor in rats

  Glucose (mg/dl) Insulin (ng/ml)
Baseline→treatment Baseline→treatment
MK-0626 + Saline 134.9 ± 6.0 →135.8 ± 7.3 2.5 ± 0.2 →2.7 ± 0.1
MK-0626 + GLP-1 2.4 pmol/kg/min 120.6 ± 7.6 →142.7 ± 14.7 2.7 ± 0.5 →2.2 ± 0.2
MK-0626 + GLP-1 4.8 pmol/kg/min 136.5 ± 7.9 →136.1 ± 8.8 1.8 ± 0.2 →1.5 ± 0.2
MK-0626 + GLP-1 9.6 pmol/kg/min 122.6 ± 4.1→131.1 ± 4.5 2.2 ± 0.2 →2.6 ± 0.4
  1. Baseline refers to the 20 minutes period prior to IV administration of saline or MK-0626.
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Cardiovascular Diabetology

ISSN: 1475-2840